Purification of .gamma.-oxo-2-dibenzofuranbutyric acid

Details Purification of .gamma.-oxo-2-dibenzofuranbutyric acid Purification of .gamma.-oxo-2-dibenzofuranbutyric acid

1972-10-30

1976-10-12

Moatz, Harry I.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424285, C07D30780

Patent

active

039857743

ABSTRACT:
A process for the separation of .gamma.-oxo-2-dibenzofuranbutyric acid from a mixture of said acid and .gamma.-oxo-3-dibenzofuranbutyric acid is disclosed. Such a mixture is obtained by the prior art method of preparing .gamma.-oxo-2-dibenzofuranbutyric acid from dibenzofuran and succinic anhydride in a Friedel-Crafts reaction. The mixture of acids is converted to a mixture of their corresponding lower alkyl esters which is separated by recrystallization or chromatography into its component alkyl esters. Hydrolysis of the lower alkyl ester of .gamma.-oxo-2-dibenzofuranbutyric acid gives the desired corresponding acid.

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