Purification of Factor VIII

Details Purification of Factor VIII Purification of Factor VIII

1979-06-22

1981-02-10

Prescott, Arthur C.

Chemistry: electrical and wave energy

Processes and products

Electrostatic field or electrical discharge

204299R, 23230B, 424 12, G01N 2726, A61K 3514, A61K 3516

Patent

active

042500087

ABSTRACT:
PCT No. PCT/GB78/00038 Sec. 371 Date June 22, 1979 Sec. 102(e) Date June 22, 1979, PCT Filed Nov. 10, 1978 PCT Pub. No. WO 79/00299 PCT Pub. Date May 31, 1979.
The invention is concerned with purification of Factor VIII containing solutions, such as blood plasma, by continuous flow electrophoresis.
Hitherto, purification of such solutions has been performed by methods such as cryoprecipitation which however have the disadvantages of poor recovery. In our invention, this problem is overcome by adjusting the pH of a Factor VIII containing solution to be in a range where the stability of Factor VIII is not adversely affected (e.g. 6 to 9) and then subjecting the solution to continuous flow electrophoresis to give purified Factor VIII fractions. If desired, the fractions may be further purified.

REFERENCES:
patent: 3870617 (1975-03-01), Bourat
patent: 3989613 (1976-11-01), Gritzner
patent: 4149957 (1979-04-01), Gibson et al.
Chem. Abstracts, vol. 54, No. 1, Jan. 10, 1960, col. 672(b).
Chem. Abstracts. vol. 52, No. 21, Nov. 10, 1958, col. 18751(g,h).

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