Purification of cephalosporins

Details Purification of cephalosporins Purification of cephalosporins

1985-01-30

1987-09-01

Kyle, Deborah L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

C07D26512

Patent

active

H00003280

ABSTRACT:
A process for purifying oxacephalosporins which comprises contacting an aqueous solution of oxacephalosporin carboxylic acid (at pH lower than its pKa) with a macroporous polymeric adsorbent (specific gravity: higher than 1.05; and saturated adsorption capacity for cephalosporin C. larger than 60 mg/ml) to adsorb and thereby separate the oxacephalosporin carboxylic acid from non-adsorbable contaminants, and then eluting the adsorbed oxacephalosporin carboxylic acid with an aqueous hydrophilic organic solvent to elute and thereby separate it from non-eluting contaminants.

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