Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1981-08-12
1983-04-19
Schain, Howard E.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
424101, C07G 700
Patent
active
043805116
ABSTRACT:
A method for removing pyrogenic material from bovine thrombin is disclosed. The method involves forming a complex of a blue dye and a polysaccharide and equilibrating the complex with a low ionic strength salt solution. Bovine thrombin is added to the complex. The pyrogenic material is removed from the bovine thrombin by washing the bovine thrombin with a low ionic strength salt solution, and the pyrogen-free bovine thrombin is recovered.
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Mannuzza Frank J.
Montalto Joseph G.
McNeil James D.
Miles Laboratories Inc.
Schain Howard E.
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