Purification of biologically active human immune interferon

Details Purification of biologically active human immune interferon Purification of biologically active human immune interferon

1984-01-18

1986-10-14

Hazel, Blondel

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Lymphokines, e.g., interferons, interlukins, etc.

424 85, 435 68, C07K 1526, C07K 328, A61K 4502, C12P 2100

Patent

active

046173781

ABSTRACT:
There is provided a process for purification of human immune interferon (IFN-.gamma.) to homogeneity without appreciable loss of biological activity by the use of chromatography on controlled-pore glass, ultrafiltration and high performance cation exchange chromatography, resulting in essentially pure human interferon subtypes 21K and 26K, and there are provided said purified interferons and pharmaceutical compositions containing same.

REFERENCES:
patent: 4168261 (1979-09-01), Edy
patent: 4440675 (1984-04-01), Braude
patent: 4485017 (1984-11-01), Tan et al.
Yip, Y. et al., Proc. Natl. Acad. Sci., vol. 79, pp. 1820-1824, 1982.

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