Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1994-02-08
1995-12-26
Marx, Irene
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435200, 435814, C12N 926
Patent
active
054787386
ABSTRACT:
This invention relates to an improved method of purifying the enzyme .alpha.-N-acetylgalactosaminidase from avian liver, as well as to the purified enzyme. The enzyme is capable of removing A antigens from the surface of cells in blood products. The method of purifying the enzyme is simple and time efficient, and lends itself to large scale production.
REFERENCES:
patent: 4330619 (1982-05-01), Goldstein
patent: 4427777 (1984-01-01), Goldstein
patent: 4609627 (1986-09-01), Goldstein
"Single-Unit Transfusions of RBC Enzymatically Converted from Group B to Group O To A and O Normal Volunteers", by Lenny et al., in Blood, vol. 77, No. 6, pp. 1383-1388 (Mar. 15, 1991).
Itoh et al J. Biochem 95 pp. 959-970 1984 .alpha.-N-acetylgalactosaminidase from Squid Liver.
"Glycosidases of Ehrlich Ascites Tumor Cells and Ascitic Fluid-Purification and Substrate Specificity of .alpha.-N-Acetylgalactosaminidase and .alpha.-Galactosidase: Comparision with Coffee Bean .alpha.-Galactosidase", by Yagi et al., in Archives of Biochemistry and Biophysics, vol. 280, No. 1, pp. 61-67 (Jul. 1990).
"Affinity Purification of .alpha.-Galactosidase A From Human Spleen, Placenta and Plasmid With Elimination of Pyrogen Contamination", by Bishop et al., in The Journal of Biological Chemistry, vol. 286, No. 3, pp. 1307-1316 (Feb. 10, 1981).
Goldstein Jack
Hurst Rosa S.
Marx Irene
New York Blood Center Inc.
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