Purification of 5-pyrimidinecarboxamides

Details Purification of 5-pyrimidinecarboxamides Purification of 5-pyrimidinecarboxamides

1986-12-08

1989-07-04

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

536 23, A61K 31515, C07D23966, C07D23968

Patent

active

048452173

ABSTRACT:
A process is provided for the purification to highly purified states of 5-pyrimidinecarboxamides which are essentially insoluble in both organic and inorganic solvents. The 5-pyrimidinecarboxamide to be purified is contacted with an organic base having a pKa value in excess of 6.95 to form an adduct. The adduct is purified through recrystallization and the desired 5-pyrimidinecarboxamide is regenerated from the adduct in highly purified form with acid. Additionally, an adduct resulting from the combination of a 5-pyrimidinecarboxamide with such an organic base is provided, which adduct is capable of being purified using recrystallization techniques, where the 5-pyrimidinecarboxamide is not itself capable of being so purified due to its relative insolubility in organic and inorganic solvents.

REFERENCES:
patent: 3961061 (1976-06-01), Kramer et al.
patent: 4283444 (1981-08-01), de Sousa et al.
patent: 4399280 (1983-08-01), de Sousa et al.
patent: 4634707 (1987-01-01), Brewer et al.
patent: 4636508 (1987-01-01), Brewer

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