Purification of 2,4,5-trifluorobenzoic acid

Details Purification of 2,4,5-trifluorobenzoic acid Purification of 2,4,5-trifluorobenzoic acid

1993-09-20

1994-08-09

Dees, Jose' G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562479, 562493, C07C 5146, C07C 5143, C07C 5142

Patent

active

053368061

ABSTRACT:
Disclosed is a process for isolating and purifying 2,4,5-trifluorobenzoic acid from a solution in a decarboxylating solvent such as NMP. The solution is neutralized with a hydroxide. This results in the formation of a salt of the 2,4,5-trifluorobenzoic acid, which precipitates. The slurry is filtered to collect the precipitated salt and the precipitated salt is dissolved in water. The aqueous solution of the salt is then acidified which results in the reformation and precipitation of the 2,4,5-trifluorobenzoic acid.

REFERENCES:
Gattermann, "The Practical Methods of Organic Chemistry," Macmillan Co. (1896), pp. 42-43.
CA 118(14):133182n (1992).
CA 101(14): 122338r (1984).
N. J. O'Reilly et al., Synlett Letters, Oct. 1990, "An Expedient Route to the Quinolone Antibacterial Intermediate, 2,4,5-Trifluorobenzoic Acid".
CA 114(11): 101357z (1990).
CA 110(1): 7855f (1987).
CA 108(22): 188895w (1986) and CA83(9): 79076z (1974).

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