Purification of 1,2-dihydro-6-alkyl-2-oxo-5-(pyridinyl)-nicotino

Details Purification of 1,2-dihydro-6-alkyl-2-oxo-5-(pyridinyl)-nicotino Purification of 1,2-dihydro-6-alkyl-2-oxo-5-(pyridinyl)-nicotino

1999-03-02

2000-09-12

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546288, 546298, C07D40104, C07D21384, C07D21362

Patent

active

061180025

ABSTRACT:
The present invention comprises a process for preparing essentially pure 1,2-dihydro-6-alkyl-2-oxo-5-(pyridinyl)-nicotinonitriles from a crude reaction mixture containing the corresponding amide as an impurity. By "essentially pure" is meant a level of purity acceptable for orally administered pharmaceutical products, usually less than 0.1% of any single impurity. At least a stoichiometric amount of an acylating agent is reacted with the crude reaction mixture, and thereafter recovering essentially pure 1,2-dihydro-6-alkyl-2-oxo 5-(pyridinyl)-nicotinonitrile.

REFERENCES:
patent: 4313951 (1982-02-01), Lesher et al.
patent: 4347363 (1982-08-01), Singh
patent: 4413127 (1983-11-01), Singh
patent: 4417054 (1983-11-01), Gelotte
patent: 4469871 (1984-09-01), Gelotte
patent: 4681944 (1987-07-01), Ippolito et al.

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