Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Patent
1994-11-21
1997-07-15
Tsang, Cecilia J.
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
530344, 530412, C07K 1400, C07K 116
Patent
active
056484577
ABSTRACT:
The present invention is directed to a purification method for hydrophobic polypeptides by using high performance liquid chromatography, characterized by using a mixed solvent as a moving phase, in which the portion of trifluoroacetic acid is from 3 to 10% by volume, and polyvinyl alcohol-based column filler in the said high performance liquid chromatography. The method according to the present invention is useful as a purification method for hydrophobic polypeptides in view of the fact that the pulmonary surfactant, which is prepared from the hydrophobic polypeptide purified according to the method of the present invention, shows better surface active property than the hydrophobic polypeptides purified by customary methods for the purification.
REFERENCES:
patent: 4894330 (1990-01-01), Hershenson et al.
Aiba Toshimitsu
Fujiwara Tetsuro
Sakai Kaoru
Takei Tsunetomo
Gupta Anism
Tokyo Tanabe Company Limited
Tsang Cecilia J.
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