Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2005-02-01
2005-02-01
Weber, Jon P. (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C530S350000, C530S815000, C536S023100, C435S006120, C435S069100, C435S325000, C435S320100, C424S422000, C424S520000
Reexamination Certificate
active
06849594
ABSTRACT:
The invention relates to purified cartilage oligomeric matrix protein (COMP), such as human COMP (hCOMP), including hCOMP prepared by purifying hCOMP in the presence of calcium (e.g. under calcium replete conditions); methods of purifying COMP in the presence of calcium; antibodies to purified hCOMP; ELISA kits comprising purified hCOMP; compositions (e.g. implants) comprising COMP; methods of repairing or producing cartilage comprising implanting a composition comprising COMP and a differentiation agent; methods for making an implant for cartilage repair comprising binding a differentiation agent to hCOMP; methods of transplanting chondrocytes and mesenchymal stem cells comprising culturing the cells in the presence of hCOMP; methods of transplanting chondrocytes comprising culturing them in the presence of hCOMP; methods of mediating attachment of cells using differentiation agent-bound COMP; methods of preparing a cartilage repair composition comprising culturing and purifying COMP in the presence of calcium and adding it to a matrix; and assays and methods of detection and quantification of COMP (e.g. degraded COMP and non-degraded COMP) and anti-COMP antibodies in a sample.
REFERENCES:
patent: 4666702 (1987-05-01), Junginger et al.
patent: 5769899 (1998-06-01), Schwartz et al.
patent: 5842477 (1998-12-01), Naughton et al.
patent: 5872094 (1999-02-01), Goetinck et al.
patent: WO 9807035 (1998-02-01), None
patent: WO 9846253 (1998-10-01), None
Hedbom et al., J. Biol. Chem 267, 6132-6136 (1992).*
Neidhart et al., British J. Rheumatology 36, 1151-1160 (1997).*
Newton, G., et al., “Characterization of Human and Mouse Cartilage Oligomeric Matrix Protein,”Genomics24 (3):435-439 (1994).
Oldberg, A., et al., “COMP (Cartilage Oligomeric Matrix Protein) Is Structurally Related to the Thrombospondins,”J. Biol. Chem.,267 (31):22346-22350 (1992).
Lawler, J., et al., “Cooperative Binding of Calcium to Thrombospondin,”J. Biol. Chem.,258:12098-12101 (1983).
DiCesare, P.E., et al., “Cartilage oligomeric matrix protein and thrombospondin 1; Purification from articular cartilage, electron microscopic structure, and chondrocyte binding,”Eur. J. Biochem.,223 (3):927-937 (1994).
Hecht, J.T., et al., “Characterization of Cartilage Oligomeric Matrix Protein (COMP) in Human Normal and Pseudoachondroplasia Musculoskeletal Tissues,”Matrix Biology,17:269-278 (1998).
Chen Hui
Lawler John W.
Chen Hui
Hamilton Brook Smith & Reynolds P.C.
Kam Chih-Min
Lawler John
Weber Jon P.
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