Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1983-06-17
1984-04-24
Schain, Howard E.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
260112R, 424 95, C07G 700, C07C10352, A61K 3736
Patent
active
044447604
ABSTRACT:
Acidic brain fibroblast growth factor isolated from bovine brain, is purified by a particular combination of protein purification techniques. The product is useful in the promotion of cell division (mitogenesis) such as in the promotion of wound healing.
REFERENCES:
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Hoffman, Growth, 4, 361-376 (1940).
Gospodarowicz et al., 3rd International Symposium on Growth Hormones, Sep. 1976.
Gospodarowicz et al. J. Biol. Chem., 253, 3736-3743 (1978).
Gospodarowicz et al., Ad. in Metabolic Disorders, vol. 8, 301-335 (1975).
Westall et al., Proc. Natl. Acad. Sci. USA, 75, 4675-4678 (1978).
Thomas et al., J. Biol. Chem. 255, 5517-5520 (1980).
Lemmon et al. J. Cell Biol. 95, 162-169 (1982).
Merck & Co. , Inc.
Monaco Mario A.
Nicholson William H.
Schain Howard E.
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