Pure, sterile, pyrogen-free hyaluronic acid formulations their m

Details Pure, sterile, pyrogen-free hyaluronic acid formulations their m Pure, sterile, pyrogen-free hyaluronic acid formulations their m

1987-05-27

1992-01-07

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 551, A61K 3170

Patent

active

050792369

ABSTRACT:
A heat stable, purified, pyrogen-free, heat sterilized fraction of hyaluronic acid suitable for use in formulations for intra-articular treatment of animals which includes minor amounts of sulphated mucopolysaccharides, sulphated ash, chlorides, solvents and less than 0.6% protein, having a molecular weight of less than 750,000 and exhibiting a specific absorbance of a 1% solution at A257nm of less than 3. A formulation for intra-articular treatment of animals including an aqueous solution of the heat stable fraction of hyaluronic acid and preservatives, such as sodium benzoate, methylparaben and propylparaben, having a pH of 6.8-8.0 at 25.degree. C. A method of preparing a formulation for intra-articular treatment of animals involving adding and dissolving methyl parahydroxybenzoate, propyl parahydroxybenzoate and sodium benzoate in hot water, mixing the preservative solution to dissolve the parabens, adding sodium hyaluronate in the solution, adjusting the pH of the resultant solution to 6.8-8.0 and diluting with water to a final volume prior to filling suitable dosages for intra-articular treatment of animals into vials which are autoclaved to sterilize the aqueous formulation. An intra-articular treatment involving injecting a suitable dosage of an aqueous solution containing a heat stable, purified, pyrogen-free, heat-sterilized fraction of hyaluronic acid into a joint of an animal suffering from a degenerative joint disease.

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