Pure potassium salt of clavulanic acid

Details Pure potassium salt of clavulanic acid Pure potassium salt of clavulanic acid

1980-05-07

1983-01-04

Berch, Mark L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424272, C07D49804, A61K 3142

Patent

active

043671756

ABSTRACT:
The invention provides the compound (2R,5R,Z)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo-[3,2,0]-heptane -2-carboxylic acid and its salts in purified form and pharmaceutical compositions containing them and a process for the purification of such compounds by conversion in aqueous media to the lithium salt of the above acid and precipitation thereof.

REFERENCES:
patent: 4301149 (1981-11-01), Crowley
Anon, Scrip #430, 10-17-79.
Beecham Data Sheet, "Augmentin-A Major Breakthru in Antibiotic Therapy", Sep. 1981.
Veitch, The Guardian of 9-12-81, "Resistant Bacteria Fall to New Drug".

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