Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Hormones – e.g. – prolactin – thymosin – growth factors – etc.
Patent
1991-10-31
1993-12-14
Knode, Marian C.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Hormones, e.g., prolactin, thymosin, growth factors, etc.
530350, 4351723, 4352523, 4353201, 435 691, C07K 1300, C12P 2102, C12N 1500
Patent
active
052704521
ABSTRACT:
Pure homogeneous glia maturation factor is disclosed with methods for producing it from neutral sources and by molecular cloning and genetic engineering.
REFERENCES:
"Purification and Characterization of Glia Maturation Factor: A Growth Regulator for Neurons and Glia", Lim, R., et al., Proc. Nat'l. Acad. Sci. USA 86: 3901-05 (1989).
Watson, J. D. et al., Recombinant DNA A Short Course, Freeman and Co. N.Y., N.Y. 1983.
Gray, P. W. et al., `Cloning and Expression of cDNA for human lymphotoxin, a lymphokine with Tumor Necrosis Activity`, Nature, vol. 312, 20/27, Dec. 1984, pp. 721-724.
Lim R. et al. `Purification of Bovine Glia Maturation Factor and Characterization with Monoclonal Antibody`, Biochemistry, 24, pp. 8070-8074, 1985.
Pouwel, P. H. et al., Cloning Vectors, A Laboratory Manual, Elsevier 1985.
Jaye Michael
Kaplan Ruth
Lim Ramon
Goodman Rosanne
Knode Marian C.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
Savitzky Martin F.
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