Pure crystalline racemic sodium parahydroxymandelate, process fo

Details Pure crystalline racemic sodium parahydroxymandelate, process fo Pure crystalline racemic sodium parahydroxymandelate, process fo

1983-01-03

1985-03-12

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C07C 5950

Patent

active

045046786

ABSTRACT:
Pure crystalline racemic sodium parahydroxymandelate free from any ions of chloride, acetate, formate and sulfate group, is manufactured by condensing in water, in the presence of sodium hydroxide at a temperature between 30.degree. and 100.degree. C., glyoxylic acid or sodium glyoxylate with an excess of phenol, concentrating it hot, until the start of crystallization of the solution thus obtained after neutralization and removal of the unconverted phenol either by steam distillation, or by extraction with a water-immiscible organic solvent. The resulting suspension obtained is cooled, drained after some hours of standing at a temperature close to 5.degree. C., and the resulting precipitate recovered by washing it with iced water followed by drying to constant weight. The product is useful for the manufacture of crystalline sodium paraformylphenolate.

REFERENCES:
patent: 4198523 (1980-04-01), Copeland
patent: 4368334 (1983-01-01), Dales

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