Pure biologically active colistin, its components and a colistin

Details Pure biologically active colistin, its components and a colistin Pure biologically active colistin, its components and a colistin

1997-02-13

1998-06-16

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 514 15, 530317, 530328, A61K 3800, A61K 3808, C07K 702, C07K 750

Patent

active

057670684

ABSTRACT:
An anti-Pseudomonas aeruginosa agent which is substantially pure biologically active colistin, its component, a mixture thereof or a pharmaceutically acceptable salt thereof delivered as an aerosol or dry powder formulation. A formulation and method for preparation of substantially pure biologically active colistin, its components, mixtures thereof and a pharmaceutically acceptable salts thereof. A method for treatment and prophylaxis of Pseudomonas aeruginosa, Stenotrophomonas maltophilia or other susceptible pulmonary bacterial infections.

REFERENCES:
patent: 5091365 (1992-02-01), Sandow et al.
Database Caplus, AN 1974:569819, Kurihara et al. Compounds related to colistin. akugaku Zasshi (1974), 94(9), 1183-7, Jan. 1984.
Newman et al. Efficient nebulization of powdered antibiotics. Int. J. Pharm. (Jan. 1987), 36(1), 55-60.
Elverdam et al. Isolation and characterization of three new polymyxins in polymixins B and E by high-performance liquid chromatography. J. Chromatography, 218, 653-661, Feb. 1981.
Kitamura-Matsunaga et al. A sodium containing polymixin derived from polymixin complex during chromatography. J. antiobiotics, 37(12), 1605-1610, Dec. 1984.
Kayaku Co., Ltd., Methacolimycin (Sodium Colistimethate), Tokyo, Japan, Literatures on Methacolimycin Chemotherapy Against Urinary Tract and Intestinal Infections, 1-49.
Kayaku Co., Ltd., Colimycin Injections Tablets, Tokyo, Japan, Antibiotics Annual, (1959-60).
J. Maddison, et al., Nebulized Colistin Causes Chest Tightness in Adults With Cystic Fibrosis, Respiratory Medicine, 145-147 (1994).
Yukio Kimura, et al., A Method For Separating Commercial Colistin Complex Into New Components: Colistins Pro-A, Pro-B and Pro-C, The Journal of Antibiotics, vol. XXXV No. 11, 1513-1520, (Nov. 1982).
John A. Bosso, et al., Research/Practice Reports, Toxicity of Colistin In Cystic Fibrosis Patients, DICP, The Annals of Pharmacotherapy, vol. 25, 1168-1170, (Nov. 1991).
A. A. Al-Khayyat, et al., Pharmacologic and Toxicologic Studies With The Polymyxins, Chemotherapy, 19:82-97, (1973).
Nebulised Colomycin For Early Pseudomonas Colonisation in Cystic Fibrosis, The Lancet, 865 (Apr. 13, 1985).
C. Vazquez, et al., Early Treatment of Pseudomonas aeruginosa Colonization in Cystic Fibrosis, Acta Paediatr, 82:308-9 (1993).
Margaret E. Hodson, MD, Msc, FRCP, DA., Cystic Fibrosis in Adolescents and Adults, The Practitioner, vol. 227, 1723-1731 (Nov. 1983).
Tim Jensen, et al., Colistin Inhalation Therapy in Cystic Fibrosis Patients With Chronic Pseudomonas aeruginosa Lung Infection, Journal of Antimicrobial Chemotherapy, 19, 831-838 (1987).
A. Bauernfeind, et al., Comparative Microbiological Effects of Combination Therapy With Ciprofloxacin Plus Colistin vs. Monotherapy With Ciprofloxacin or Colistin Against Pseudomonas aeruginosa, Abstracts, International Cystic Fibrosis Symposium (Sep. 26-28, 1996), Monatsschr Kinderheilkd 144:1028 & 1042 (1996).
Niels H. Valerius, et al., Prevention of Chronic Pseudomonas aeruginosa Colonisation in Cystic Fibrosis by Early Treatment, The Lancet, vol. 338, 725-726 (Sep. 21, 1991).

Affiliated with

Also associated with

Rating

Pure biologically active colistin, its components and a colistin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pure biologically active colistin, its components and a colistin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pure biologically active colistin, its components and a colistin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1726018