Pulsed low frequency EPR spectrometer and imager

Electricity: measuring and testing – Particle precession resonance – Using an electron resonance spectrometer system

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G01R 3320

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055023860

ABSTRACT:
An EPR imager and spectrometer includes pulse generating system for generating broadband pulses having an RF carrier frequency that is not highly absorbed by biological samples. The pulse generating system includes up and down chirp convertors for frequency modulating a carrier frequency pulse and compressing the frequency modulated pulse to form a broadband excitation pulse of high energy. Such a machine could form the basis of a clinical imaging device capable of high sensitivity to free radical species in human patients.

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Review of Scientific Instruments, vol. 63, No. 10, Oct. 1, 1992, New York, N.Y., pp. 4263-4270, M. Alecci, et al., "Electron Paramagnetic Resonance Spectrometer for Three-Dimensional in Vivo Imaging at Very Low Frequency".
Journal of Magnetic Resonance, vol. 103, No. 2, Jun. 15, 1993, Orlando, Minn., pp. 226-229, V. L. Ermakov, et al., "Improved Schemes for Refocusing with Frequency-Modulated Chirp Pulses".
Journal of Magnetic Resonance, vol. 92, No. 3, May 1, 1991, Orlando, Minn., pp. 480-489, J. A. Brivati, et al., "A Radiofrequency ESR Spectrometer for in Vivo Imaging".
Review of Scientific Instruments, vol. 60, No. 6, Jun. 1, 1989, New York, N.Y., pp. 1040-1050, H. J. Halpern, et al., "Imaging Radio Frequency Electron-Spin-Resonance Spectrometer with High Resolution and Sensitivity for in Vivo Measurements".

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