Chemistry: molecular biology and microbiology – Apparatus – Bioreactor
Reexamination Certificate
2004-12-09
2009-10-27
Ketter, James S (Department: 1636)
Chemistry: molecular biology and microbiology
Apparatus
Bioreactor
Reexamination Certificate
active
07608447
ABSTRACT:
Disclosed is a novel net member for supporting one or more cell constructs in the culture chamber of a bioreactor, which comprises an array of impermeable pyramidal elements protruding from the face thereof, wherein each of the corners of the base of each of said impermeable pyramidal elements comprises a circular opening. This net member provides for uniform and unobstructed flow of culture medium through 3D cell constructs in culture.Also disclosed are a bioreactor and bioreactor system incorporating said net member.The bioreactor and bioreactor system may be used in the bioproduction of therapeutic proteins and stem cell expansion.
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Shachar M., et al., (2003) Ex-vivo engineering of cardiac muscle: Cultivation in rotating vessels. Proceedings of EMCC-Bioengineering.
Cohen Smadar
Dvir Tal
Shachar Michal
Ben Gurion University of the Negev Research and Development Auth
Ketter James S
McCarthy Kevin D.
Roach Brown McCarthy & Gruber P.C.
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