Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1993-06-23
1994-09-20
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424458, 424461, 424462, 424490, 424493, 424495, 424497, 424498, A61K 954, A61K 956, A61K 958
Patent
active
053487486
ABSTRACT:
Pharmaceutical delivery systems containing 7-dimethyl-6-deoxy-6-demethyltetracycline or a non-toxic acid addition salt thereof comprising mixtures of a minor proportion of slow-release blended polymer coated spherical granules adapted to release part of the minocycline in a medium having a pH of below 3.9 and the rest in the range of from about 4.0 to about 7.5 and a major proportion of coated or uncoated quick-release granules adapted to release minocycline in a medium having a pH of less than about 3.9 and oral dosage unit form capsules containing the above are provided. These systems and formulations provide enhanced therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day, regardless of whether the patient is fed or fasted. Methods for the preparation of the systems and formulations are provided as well.
REFERENCES:
patent: 3080294 (1963-03-01), Shepard
patent: 3865935 (1975-02-01), Amann
patent: 4138475 (1979-02-01), McAnish et al.
patent: 4173626 (1979-11-01), Dempski et al.
patent: 4250166 (1981-02-01), Maekawa et al.
patent: 4353887 (1982-10-01), Hess et al.
patent: 4606909 (1986-08-01), Bechgaard et al.
patent: 4784858 (1988-11-01), Ventouras
patent: 4808413 (1989-02-01), Joshi et al.
patent: 4837030 (1989-06-01), Valorose, Jr. et al.
patent: 5133974 (1992-07-01), Paradissis et al.
patent: 5275824 (1994-01-01), Carli et al.
patent: 5283065 (1994-02-01), Doyon et al.
patent: 5286497 (1994-02-01), Hendrickson et al.
Abstract Japan Appln. No. 51-139712 and Japanese text.
Abstract Japan Appln. No. 62-226926 and Japanese text.
Ellway Keith A.
Ganesan MaduraiGurusamy
Johnson Jerry B.
Mooney Kieran G.
Sheth Nitin V.
American Cyanamid Company
Costigan James
Page Thurman K.
Spear James M.
LandOfFree
Pulsatile once-a-day delivery systems for minocycline does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pulsatile once-a-day delivery systems for minocycline, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pulsatile once-a-day delivery systems for minocycline will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2429680