Pulsatile once-a-day delivery systems for minocycline

Details Pulsatile once-a-day delivery systems for minocycline Pulsatile once-a-day delivery systems for minocycline

1993-07-14

1995-05-09

Page, Thurman H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424458, 424459, 424461, 424462, 424468, 424470, 424489, 424494, 424497, 514937, A61K 914, A61K 916, A61K 954, A61K 956

Patent

active

054137772

ABSTRACT:
Pharmaceutical delivery systems containing 7-dimethyl-6-deoxy-6-demethyltetracycline or a non-toxic acid addition salt thereof comprising mixtures or separate administration units of pH sensitive polymer coated spherical granules adapted to release the minocycline in a medium having a pH of in the range of from about 4.0 to about 7.5 and coated or uncoated quick release granules adapted to release minocycline in a medium having a pH of less than about 3.9 or minocycline powder, pH adapted multi-coated compositions and oral dosage unit form liquids, capsules or tablets containing the above are provided. These systems and formulations provide at least minimum therapeutic blood levels of minocycline for at least about 24 hours when administered to a subject only once-a-day. Methods for the preparation of the systems and formulations are provided as well.

REFERENCES:
Abstract Japan Appln. No. 62-226926 and Japanese text.
Abstract Japan Appln. No. 52-139713 & Japanese Text.

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