Pulsatile flow system for developing heart valves

Details Pulsatile flow system for developing heart valves Pulsatile flow system for developing heart valves

1997-03-05

1999-05-04

Isabella, David J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Heart valve

Having rigid or semirigid pivoting occluder

738656, A61F 224, A61F 276

Patent

active

058999370

ABSTRACT:
A closed, sterile pulsatile flow loop for studying tissue valves. The system provides both a tool to examine heart valve leaflet fibroblast function and differentiation as these are affected by mechanical loading, as well as an apparatus to provide heart valves seeded with suitable cells. The sterile pulsatile flow system provides a left heart duplicator, which exposes viable tissue valves to a dynamic flow environment imitating that of the aortic valve.

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High-amplitude pulsatile pump in extracorporeal circulation with particular reference to hemodynamics; J. Thoracic Surg., pp. 798-808, Nov. 1963.

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