Pulsatile drug delivery system

Details Pulsatile drug delivery system Pulsatile drug delivery system

1991-10-07

1993-07-20

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424464, 424473, 424480, A61K 948

Patent

active

052291316

ABSTRACT:
A drug delivery system for administering a drug in controlled pulse doses to an aqueous environment in the body of a living being has one or more, and preferably less than ten, individual drug-containing subunits in a unitary drug depot, such as a tablet or capsule. The individual subunits are designed to dissolve at different sites and/or times in the gastrointestinal tract to release pulse doses of drug into the portal system in an analogous manner to the rate of release from an immediate release dosage form administered according to an appropriate dosing schedule. The dissolution time of the individual subunits can be controlled by several methods including the provision of pH-sensitive enteric coatings and permeability-controlled coatings. The drug delivery system has significant advantages for the oral administration of first-pass metabolized drugs which exhibit a non-linear relationship between input rate of the drug into the portal system and bioavailability.

REFERENCES:
patent: 4773907 (1988-09-01), Urquhart
patent: 4777049 (1988-10-01), Magruder
patent: 4783337 (1988-08-01), Wong

Affiliated with

Also associated with

Rating

Pulsatile drug delivery system does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pulsatile drug delivery system, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pulsatile drug delivery system will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1758910