Pulmonary surfactant proteins and related polypeptides

Details Pulmonary surfactant proteins and related polypeptides Pulmonary surfactant proteins and related polypeptides

1995-04-11

1998-08-04

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

424450, 530326, A61K 3816

Patent

active

057893810

ABSTRACT:
The present invention discloses useful peptides and synthetic pulmonary surfactants, as well as methods of making and using same. In one preferred embodiment, a synthetic pulmonary surfactant comprises one or more pharmaceutically acceptable phospholipids admixed with a polypeptide comprising at least 10 amino acid residues and no more than about 60 amino acid residues, said polypeptide including a sequence having alternating hydrophobic and hydrophilic amino acid residue regions. In other embodiments, a surfactant peptide has an amino acid residue sequence selected from the group consisting of KLLLLKLLLLKLLLLKLLLLK, KLLLLLLLLKLLLLLLLLKLL, and KKLLLLLLLKKLLLLLLLKKL.

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patent: 5164369 (1992-11-01), Cochrane et al.
patent: 5260273 (1993-11-01), Cochrane et al.
patent: 5407914 (1995-04-01), Cochrane et al.

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