Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1987-09-24
1989-11-21
Kight, John
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
530808, 435 68, 435 70, 935 60, C07K 1300, A61K 3702
Patent
active
048824224
ABSTRACT:
This invention relates to novel proteins useful for enhancing pulmonary surfactant activity, methods for obtaining said proteins and compositions containing one or more of the proteins. The proteins of this invention include the following:
REFERENCES:
patent: 4659805 (1987-04-01), Schilling, Jr. et al.
Weinberg et al, "Isolation and Characterization of Humawn Apolipoprotein A-IV from Lipoprotein-Depleted Serum", J. Lipid Res., vol. 24, 1983, pp. 52-59.
Utermann et al, "Apolipoprotein A-IV: A Protein Occurring in Human Mesenteric Lymph Chylomicrons and Free in Plasma", Eur. J. Biochem. 99, 333-343 (1979).
Weisgraber et al, "Isolation and Characterization of an Apoprotein from the d>1.006 Lipoproteins of Human and Canine Lymph Homologous with the Rat A-IV Apoprotein", Biochem Biophys Res Comm, vol. 85, No. 1, 1978, pp. 287-292.
Green et al, "Human Apolipoprotein A-IV-Intestinal Origin and Distribution in Plasma", J. Clin. Invest., vol. 65, Apr. 1980, 911-919.
Beisiegel et al, "An Apolipoprotein Homolog of Rat Apolipoprotein A-IV in Human Plasma", Eur. J. Biochem, 93, 601-608 (1979).
Floros et al, "Biosynthesis and in Vitro Translation of the Major Surfactant-Associated Protein from Human Lung", J. of Biol Chem., vol. 260, No. 1, 495-500, Jan. 10, 1985.
Hawgood et al, "Effects of a Surfactant-Assocaited Protein and Calcium Ion on the Structure and Surface Activity of Lung Surfactant Lipids", Biochemistry, 1984, 24, 184-190.
Bhattacharyya et al, "Isolation and Characterization of Two Hydroxyproline-Containing Glycoproteins from Normal Animal Lung Lavage and Lamellar Bodies", J. Clin Invest., vol. 55, May 1975, 914-920.
Floros Joanna
Fritsch Edward F.
Jacobs Kenneth A.
Phelps David S.
Steinbrink D. Randall
Berstein David L.
Eisen Bruce M.
Genetics Institute Inc.
Kight John
Nutter Nathan M.
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