Pulmonary surfactant protein and related polypeptide

Details Pulmonary surfactant protein and related polypeptide Pulmonary surfactant protein and related polypeptide

1989-01-04

1992-11-17

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, 530324, 530325, 530326, C07K 708, C07K 710, A61K 3702

Patent

active

051643693

ABSTRACT:
The present invention relates to a human SP18 monomer protein-related polypeptide useful in forming a synthetic pulmonary surfactant. The present invention also relates to a method of treating neonatal respiratory distress syndrome comprising adminstering a therapeutically effective amount of synthetic pulmonary of the present invention. Further contemplated by the present invention is a composition containing human SP18 monomer and human SP18 dimer but no other pulmonary surfactant proteins. A recombinant DNA molecule capable of expressing, without post-translational proteolytic processing, mature human SP18 monomer, and methods of using the recombinant DNA molecule are also contemplated.

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