Pulmonary surfactant peptide solubilization process

Details Pulmonary surfactant peptide solubilization process Pulmonary surfactant peptide solubilization process

1996-10-22

1998-04-21

Davenport, Avis M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

15 to 23 amino acid residues in defined sequence

530345, 530333, 514 13, A61K 3800, C07K 500, C07K 700

Patent

active

057418918

ABSTRACT:
The invention relates to a method of manufacturing pulmonary surfactant protein by solubilizing the protein in ethanol by treatment with a fluorinated alcohol so that the protein may be formulated into liposomes by ethanolic injection.

REFERENCES:
patent: 4861756 (1989-08-01), Jackson
patent: 5164369 (1992-11-01), Cochrane et al.
International Search Report--International Application No. PCT/US96/16804--International Filing Date 22, Oct. 1996.
Database Medline, Abstract 93360135, XP2024935, Journal of Pharmacology and Experimental Therapeutics, (1993 Aug.) 266 (2) 551-6.
Database Medline, Abstract 93312859, XP2024934, Biochimica et Biophysica Acta, (1993 Jul. 1) 1168 (3) 261-70.

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