Pulmonary surfactant

Details Pulmonary surfactant Pulmonary surfactant

1983-08-04

1989-05-09

Chan, Nicky

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

514148, A61K 914

Patent

active

048288446

ABSTRACT:
A pulmonary surfactant for the treatment of dyspnea syndromes, containing dipalmitoyl phosphatidyl choline (DPPC) and dipalmitoyl phosphatidyl glycerol (DPPG) in a ratio of from 9:1 to 8:2 and a sugar, in the form of a redispersable powder, which is obtained by dissolving the phospholipids in glacial acetic acid, adding the sugar, and finally freeze-drying of the mixture. The lyophilisate is redispersed in a suitable buffer solution for application.

REFERENCES:
patent: 2414918 (1947-01-01), Abramson
patent: 3197368 (1965-07-01), Lappe
patent: 3594476 (1971-07-01), Merrill
patent: 4252796 (1981-02-01), Yu et al.
CA 99:65086w.
Freese et al. "Effects of Betamethasone and Fetal Sex on the Synthesis and maturation of Lung Surfactant Phosphalipids in Rabbits", Biochim. Biophys. Acta 750(1) 47-59, 1983.
Engle et al., "Type II Alicolar Cells in OrganoTypic Culture A Model System for the Study of Surfactant Synthesis, Biochem, BiophyseActa" 617(2) 225-236 (1980).
Rabinowitz et al. "Reutilization of Fatty Acid Carbons for Lung Lipid Synthesis", Am. J. Physiol. 1981, 240(4) E435-E440 (CA94:171661m).

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