Pulmonary delivery of active fragments of parathyroid hormone

Details Pulmonary delivery of active fragments of parathyroid hormone Pulmonary delivery of active fragments of parathyroid hormone

2007-11-27

2007-11-27

Lukton, David (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S324000, C530S399000, C424S045000, C424S469000, C424S489000

Reexamination Certificate

active

10245707

ABSTRACT:
Systemic delivery of parathyroid hormone to a mammalian host is accomplished by inhalation through the mouth of a dispersion of an N-terminal fragment of PTH. It has been found that such respiratory delivery of the PTH fragment provides a pulsatile concentration profile of the PTH in the host's serum. PTH fragment compositions include dry powder formulations having the PTH present in a dry bulking powder, liquid solutions or suspensions suitable for nebulization, and aerosol propellants suitable for use in a metered dose inhaler.

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