Pulmonary delivery of active fragments of parathyroid hormone

Details Pulmonary delivery of active fragments of parathyroid hormone Pulmonary delivery of active fragments of parathyroid hormone

1996-03-28

1998-09-29

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530324, 530399, 424 45, 424469, A61K 3829

Patent

active

058146075

ABSTRACT:
Systemic delivery of parathyroid hormone to a mammalian host is accomplished by inhalation through the mouth of a dispersion of an N-terminal fragment of PTH. It has been found that such respiratory delivery of the PTH fragment provides a pulsatile concentration profile of the PTH in the host's serum. PTH fragment compositions include dry powder formulations having the PTH present in a dry bulking powder, liquid solutions or suspensions suitable for nebulization, and aerosol propellants suitable for use in a metered dose inhaler.

REFERENCES:
patent: 4698328 (1987-10-01), Neer et al.
patent: 4833125 (1989-05-01), Neer et al.
patent: 5011678 (1991-04-01), Wang et al.
patent: 5230884 (1993-07-01), Evans et al.
patent: 5302581 (1994-04-01), Sarin et al.
patent: 5458135 (1995-10-01), Patton et al.
English abstract of Japanese document JP 02-000111, Jan. 5, 1990.
Habener et al. (1971) Proc. Natl. Acad. Sci. USA 68:2986-2991.
Harms et al. (1987) Int. Symp. on Osteoporosis, Aalborg, Abstr. 232, pp. 723-724.
Hesch et al. (1988) Calcif. Tissue Int. 42:341-344.
Neer et al. (1987) Osteoporosis 53:829-835.
Patton et al. (1992) Adv. Drug Delivery Reviews 8:179-196.
Patton (1994) J Controlled Release 28, 79.

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