Pulmonary administration of granulocyte colony stimulating facto

Details Pulmonary administration of granulocyte colony stimulating facto Pulmonary administration of granulocyte colony stimulating facto

1992-09-29

1994-02-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424 43, 424 46, 424 851, 424434, 514 2, 514 8, 514 21, 514885, 514951, 530350, 530395, 530397, 530838, A61K 914, A61K 4505, C07K 1710, C07K 1514

Patent

active

052846563

ABSTRACT:
Granulocyte-colony stimulating factor (G-CSF) can be delivered systemically in therapeutically or prophylactically effective amounts by pulmonary administration using a variety of pulmonary delivery devices, including nebulizers, metered dose inhalers and powder inhalers. Aerosol administration in accordance with this invention results in significant elevation of the neutrophil levels that compares favorably with delivery by subcutaneous injection. G-CSF can be administered in this manner to medically treat neutropenia, as well as to combat or prevent infections.

REFERENCES:
patent: 4833127 (1989-05-01), Ono et al.
patent: 4961926 (1990-10-01), Gabrilove
patent: 5043156 (1991-09-01), Matsumoto et al.

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