PUFA polyketide synthase systems and uses thereof

Details PUFA polyketide synthase systems and uses thereof PUFA polyketide synthase systems and uses thereof

2011-03-15

2011-03-15

Kim, Alexander D (Department: 1656)

Multicellular living organisms and unmodified parts thereof and

Plant, seedling, plant seed, or plant part, per se

C435S252100, C435S134000, C800S281000

Reexamination Certificate

active

07906706

ABSTRACT:
Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganismsShewanella japonicaandShewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.

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