Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-07-16
2010-11-23
Nashed, Nashaat T (Department: 1656)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S069100, C435S134000, C435S189000, C435S252300, C435S252700, C435S320100, C435S419000
Reexamination Certificate
active
07838649
ABSTRACT:
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
REFERENCES:
patent: 5130242 (1992-07-01), Barclay et al.
patent: 5246841 (1993-09-01), Yazawa et al.
patent: 5310242 (1994-05-01), Golder
patent: 5639790 (1997-06-01), Voelker et al.
patent: 5672491 (1997-09-01), Khosia et al.
patent: 5683898 (1997-11-01), Yazawa et al.
patent: 5798259 (1998-08-01), Yazawa et al.
patent: 5908622 (1999-06-01), Barclay
patent: 6033883 (2000-03-01), Barr et al.
patent: 6140486 (2000-10-01), Facciotti et al.
patent: 6503706 (2003-01-01), Abken et al.
patent: 6566583 (2003-05-01), Facciotti et al.
patent: 7001772 (2006-02-01), Roessler et al.
patent: 7125672 (2006-10-01), Picataggio et al.
patent: 7211418 (2007-05-01), Metz et al
patent: 7214853 (2007-05-01), Facciotti et al.
patent: 7217856 (2007-05-01), Weaver et al.
patent: 7256022 (2007-08-01), Metz et al.
patent: 7256023 (2007-08-01), Metz et al.
patent: 7259295 (2007-08-01), Metz et al.
patent: 7271315 (2007-09-01), Metz et al.
patent: 2002/0138874 (2002-09-01), Mukerji et al.
patent: 2002/0156254 (2002-10-01), Qiu et al.
patent: 2002/0194641 (2002-12-01), Metz et al.
patent: 2004/0005672 (2004-01-01), Santi et al.
patent: 2004/0010817 (2004-01-01), Shockey et al.
patent: 2004/0139498 (2004-07-01), Jaworski et al.
patent: 2004/0172682 (2004-09-01), Kinney et al.
patent: 2005/0014231 (2005-01-01), Mukerji et al.
patent: 2005/0089865 (2005-04-01), Napier et al.
patent: 2005/0164192 (2005-07-01), Graham et al.
patent: 2007/0244192 (2007-10-01), Metz
patent: 2007/0245431 (2007-10-01), Metz et al.
patent: 2007/0256146 (2007-11-01), Metz et al.
patent: 2007/0270494 (2007-11-01), Metz et al.
patent: 2008/0022422 (2008-01-01), Weaver et al.
patent: 2008/0026434 (2008-01-01), Weaver et al.
patent: 2008/0026435 (2008-01-01), Weaver et al.
patent: 2008/0026438 (2008-01-01), Metz et al.
patent: 2008/0026439 (2008-01-01), Metz et al.
patent: 2008/0026440 (2008-01-01), Metz et al.
patent: 2008/0032351 (2008-02-01), Metz et al.
patent: 2008/0038378 (2008-02-01), Metz et al.
patent: 2008/0038379 (2008-02-01), Metz et al.
patent: 2008/0038790 (2008-02-01), Metz et al.
patent: 2008/0038791 (2008-02-01), Metz et al.
patent: 2008/0038792 (2008-02-01), Metz et al.
patent: 2008/0038793 (2008-02-01), Metz et al.
patent: 2008/0038794 (2008-02-01), Metz et al.
patent: 2008/0038795 (2008-02-01), Metz et al.
patent: 2008/0038796 (2008-02-01), Metz et al.
patent: 2008/0038797 (2008-02-01), Metz et al.
patent: 2008/0040822 (2008-02-01), Metz et al.
patent: 2008/0044867 (2008-02-01), Metz et al.
patent: 2008/0044868 (2008-02-01), Metz et al.
patent: 2008/0044869 (2008-02-01), Metz et al.
patent: 2008/0044870 (2008-02-01), Metz et al.
patent: 2008/0044871 (2008-02-01), Metz et al.
patent: 2008/0044872 (2008-02-01), Metz et al.
patent: 2008/0044873 (2008-02-01), Metz et al.
patent: 2008/0050790 (2008-02-01), Metz et al.
patent: 2008/0148433 (2008-06-01), Metz et al.
patent: 2520795 (2004-10-01), None
patent: 0594868 (1994-05-01), None
patent: 0823475 (1998-02-01), None
patent: 9323545 (1993-11-01), None
patent: 9621735 (1996-07-01), None
patent: 9846764 (1998-10-01), None
patent: 9855625 (1998-12-01), None
patent: 0042195 (2000-07-01), None
patent: WO 02/083870 (2002-10-01), None
patent: WO 2004/087879 (2004-10-01), None
patent: WO 2006/008099 (2006-01-01), None
patent: WO 2006/034228 (2006-03-01), None
Abbadi et al., Eur. J. Lipid Sci. Technol., 103:106-113 (2001).
Allen et al., Appl. Envir. Microbiol., 65(4):1710-1720 (1999).
Bateman et al., Nucl. Acids Res., 30(1):276-280 (2002).
Bentley et al., Annu. Rev. Microbiol., 53:411-46 (1999).
Bisang et al., Nature, 401:502-505 (1999).
Bork, TIG, 12(10):425-427 (1996).
Brenner, TIG, 15(4):132-133 (1999).
Broun et al., Science, 282:1315-1317 (1998).
Creelman et al., Annu. Rev. Plan Physiol. Plant Mol. Biol., 48:355-81 (1997).
DeLong & Yayanos, Appl. Environ. Microbiol., 51(4):730-737 (1986).
Doerks, TIG, 14(6):248-250 (1998).
Facciotti et al., “Cloning and Characterization of Polyunsaturated Fatty Acids (PUFA) Genes from Marine Bacteria” in Proceedings of the international symposium on progress and prospect of marine biotechnology (China Ocean Pres 1999), pp. 404-405 Abstract.
Heath et al., J. Biol. Chem., 271(44):27795-27801 (1996).
Hopwood & Sherman, Annu. Rev. Genet., 24:37-66 (1990).
Hutchinson, Annu. Rev. Microbiol., 49:201-238 (1995).
Jostensen & Landfald, FEMS Microbiology Letters, 151:95-101 (1997).
Katz & Donadio, Annu. Rev. Microbiol., 47:875-912 (1993).
Kealing et al., Curr. Opin. Chem. Biol., 3:598-606 (1999).
Kyle et al., HortScience, 25:1523-26 (1990).
Magnuson, Microbil. Rev., 57(3):522-542 (1993) Abstract.
Metz et al., Science, 293:290-293 (2001).
Nakahara, Yukagaku, 44(10):821-7 (1995).
Nasu et al., J. Ferment. Bioeng., 122:467-473 (1997).
Nichols et al., Curr. Opin. Biotechnol., 10:240-246 (1999).
Nogi et al., Extremophiles, 2:1-7 (1998).
Parker-Barnes et al., PNAS, 97(15):8284-8289 (2000).
Sánchez et al., Chemistry & Biolosy, 8:725-738 (2001).
Shanklin et al., Annu. Rev. Plant Physiol. Plant Mol. Biol., 49:611-41 (1998).
Smith et al., Nature Biotechnol., 15:1222-1223 (1997).
Somerville Am. J. Clin. Nutr., 58(2 supp):270S-275S (1993).
Van de Loo, Proc. Natl. Acad. Sci. USA, 92:6743-6747 (1995).
Watanabe et al., J. Biochem., 122:467-473 (1997).
Yalpani et al., The Plant Cell, 13:1401-1409 (2001).
Yazawa, Lipids, 31(supp):S297-S300 (1996).
Metz et al. Production of Polyunsaturated Fatty Acids by Polyketide Synthase in Both Prokaryotes and Eukaryotes. Science Jul. 12, 2001, vol. 293, pp. 290-293.
Qiu et al. Identification of a delta4 fatty acid desaturase fromThraustochytriumsp. involved in the biosynthesis. J. Biol. Chem. Aug. 24, 2001, vol. 276, No. 34, pp. 31561-31566.
Yokochi et al. Optimization of docosahexaenoic acid production. App. Microbiol. Biotechnol. 1998, vol. 49, pp. 72-76.
Nakahara et al. Production of docosahexaenoic and docosapentaenoic acids bySchizochytriumsp. isloated from Yap Islands. 1996 J. Am. Oil Chem. Soc. 1996, vol. 73, No. 11, pp. 1421-1426.
Weete et al. Lipids and Ultrasctructure ofThrauchytriumsp. ATCC26185. 1997, Am Oil Chem. Soc. vol. 32, No. 8, pp. 839-845.
Singh et al. Microbial Production of Docosahexaenoic Acid (DHA, C22:6) Adv. Appl. Microbial, 1997. vol. 45, pp. 271-312.
Fan K W et al: “Eicosapentaenoic and docosahexaenoic acids production by and okara-utilizing potential of thraustochytrids” Journal of Industrial Microbiology and Biotechnology, Basingstoke, GB, vol. 27, No. 4, Oct. 1, 2001, pp. 199-202, XP002393382 ISSN: 1367-5435.
Wolff et al, Arachidonic, Eicosapentaenoic and Biosynthetically Related Fatty Acids in Seed Lipids from a primitive Gymnosperm,Agathis robusta. Lipids 34(10), 1994, 1083-1097.
Grimsley et al, “Fatty acid composition of mutants of the mossPhyscomitrella patens” Phytochemistry 20(7): 1519-1524, 1981.
Bedford et al, “A functional chimeric modular polyketide synthase generated via domain replacement.” Chemistry & Biology 3: 827 -831, Oct. 1996.
Sequence alignment for SEQ ID No. 5 with SEQID No. 17 from US Patent 5,683,898. Search resulted dated Aug. 5, 2009.
Sequence alignment for SEQ ID No. 1 with SEQID No. 16 from US Patent 5,683,898. Search resulted dated Aug. 5, 2009.
Sequence alignment of SEQ ID No. 7 with SEQ ID No. 1 of Yazawa, US Patent 5,798,259, search result date Aug. 10,2009.
Sequence alignment of SEQ ID No. 11 with SEQ ID No. 16 of Yazawa, US Patent 5,798,259, search result date Aug. 10, 2009.
U.S. Appl. No. 11/674,574, filed Feb. 13, 2007, Facciotti et al.
U.S. Appl.
Barclay William R.
Flatt James H.
Metz James G.
Weaver Craig A.
Martek Biosciences Corporation
Moore William W
Nashed Nashaat T
Sterne Kessler Goldstein & Fox P.L.L.C.
LandOfFree
PUFA polyketide synthase systems and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with PUFA polyketide synthase systems and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and PUFA polyketide synthase systems and uses thereof will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4252276