PUFA polyketide synthase systems and uses thereof

Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Bacteria or actinomycetales; media therefor

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S134000, C435S189000, C435S254110, C435S257200, C536S023200

Reexamination Certificate

active

07807442

ABSTRACT:
The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.

REFERENCES:
patent: 5130242 (1992-07-01), Barclay et al.
patent: 5246841 (1993-09-01), Yazawa et al.
patent: 5310242 (1994-05-01), Golder
patent: 5639790 (1997-06-01), Voelker et al.
patent: 5672491 (1997-09-01), Khosla et al.
patent: 5683898 (1997-11-01), Yazawa et al.
patent: 5798259 (1998-08-01), Yazawa et al.
patent: 5908622 (1999-06-01), Barclay
patent: 6033883 (2000-03-01), Barr et al.
patent: 6140486 (2000-10-01), Facciotti et al.
patent: 6503706 (2003-01-01), Abken et al.
patent: 6566583 (2003-05-01), Facciotti et al.
patent: 6677145 (2004-01-01), Mukerji et al.
patent: 7001772 (2006-02-01), Roessler et al.
patent: 7087432 (2006-08-01), Qiu et al.
patent: 7125672 (2006-10-01), Picataggio et al.
patent: 7208590 (2007-04-01), Mukerji et al.
patent: 7211418 (2007-05-01), Metz et al
patent: 7214853 (2007-05-01), Facciotti et al.
patent: 7217856 (2007-05-01), Weaver et al.
patent: 7247461 (2007-07-01), Metz et al.
patent: 7256022 (2007-08-01), Metz et al.
patent: 7256023 (2007-08-01), Metz et al.
patent: 7259295 (2007-08-01), Metz et al.
patent: 7271315 (2007-09-01), Metz et al.
patent: 2004/0005672 (2004-01-01), Santi et al.
patent: 2004/0010817 (2004-01-01), Shockey et al.
patent: 2004/0139498 (2004-07-01), Jaworski et al.
patent: 2004/0172682 (2004-09-01), Kinney et al.
patent: 2005/0089865 (2005-04-01), Napier et al.
patent: 2005/0164192 (2005-07-01), Graham et al.
patent: 2007/0244192 (2007-10-01), Metz
patent: 2007/0245431 (2007-10-01), Metz et al.
patent: 2007/0256146 (2007-11-01), Metz et al.
patent: 2007/0266455 (2007-11-01), Weaver et al.
patent: 2007/0270494 (2007-11-01), Metz et al.
patent: 2008/0022422 (2008-01-01), Weaver et al.
patent: 2008/0026434 (2008-01-01), Weaver et al.
patent: 2008/0026435 (2008-01-01), Weaver et al.
patent: 2008/0026436 (2008-01-01), Weaver et al.
patent: 2008/0026437 (2008-01-01), Weaver et al.
patent: 2008/0026438 (2008-01-01), Metz et al.
patent: 2008/0026439 (2008-01-01), Metz et al.
patent: 2008/0026440 (2008-01-01), Metz et al.
patent: 2008/0032296 (2008-02-01), Weaver et al.
patent: 2008/0032338 (2008-02-01), Weaver et al.
patent: 2008/0032351 (2008-02-01), Metz et al.
patent: 2008/0032367 (2008-02-01), Weaver et al.
patent: 2008/0032368 (2008-02-01), Weaver et al.
patent: 2008/0032369 (2008-02-01), Weaver et al.
patent: 2008/0038379 (2008-02-01), Metz et al.
patent: 2008/0038790 (2008-02-01), Metz et al.
patent: 2008/0038792 (2008-02-01), Metz et al.
patent: 2008/0038793 (2008-02-01), Metz et al.
patent: 2008/0038794 (2008-02-01), Metz et al.
patent: 2008/0038795 (2008-02-01), Metz et al.
patent: 2008/0038796 (2008-02-01), Metz et al.
patent: 2008/0038797 (2008-02-01), Metz et al.
patent: 2008/0038798 (2008-02-01), Weaver et al.
patent: 2008/0038799 (2008-02-01), Weaver et al.
patent: 2008/0040822 (2008-02-01), Metz et al.
patent: 2008/0044867 (2008-02-01), Metz et al.
patent: 2008/0044868 (2008-02-01), Metz et al.
patent: 2008/0044869 (2008-02-01), Metz et al.
patent: 2008/0044870 (2008-02-01), Metz et al.
patent: 2008/0044871 (2008-02-01), Metz et al.
patent: 2008/0044872 (2008-02-01), Metz et al.
patent: 2008/0044873 (2008-02-01), Metz et al.
patent: 2008/0044874 (2008-02-01), Weaver et al.
patent: 2008/0050790 (2008-02-01), Metz et al.
patent: 2008/0050791 (2008-02-01), Weaver et al.
patent: 2008/0148433 (2008-06-01), Metz et al.
patent: 2520795 (2004-10-01), None
patent: 0594868 (1994-05-01), None
patent: 0823475 (1998-02-01), None
patent: WO 93/23545 (1993-11-01), None
patent: WO 96/21735 (1996-07-01), None
patent: WO 98/46764 (1998-10-01), None
patent: WO 98/55625 (1998-12-01), None
patent: WO 00/42195 (2000-07-01), None
patent: WO 02/083870 (2002-10-01), None
patent: WO 2004/087879 (2004-10-01), None
patent: WO 2006/008099 (2006-01-01), None
patent: WO 2006/034228 (2006-03-01), None
U.S. Appl. No. 11/689,587, filed Mar. 22, 2007, Metz et al.
U.S. Appl. No. 11/689,596, filed Mar. 22, 2007, Metz et al.
U.S. Appl. No. 11/689,598, filed Mar. 22, 2007, Metz et al.
U.S. Appl. No. 11/689,605, filed Mar. 22, 2007, Metz et al.
U.S. Appl. No. 11/689,608, filed Mar. 22, 2007, Metz et al.
U.S. Appl. No. 11/777,220, filed Jul. 12, 2007, Metz et al.
U.S. Appl. No. 11/777,277, filed Jul. 12, 2007, Metz et al.
U.S. Appl. No. 11/777,278, filed Jul. 12, 2007, Metz et al.
U.S. Appl. No. 11/777,279, filed Jul. 12, 2007, Metz et al.
Abbadi et al., Eur. J. Lipid Sci. Technol., 103:106-113 (2001).
Allen et al., Appl. Envir. Microbiol., 65(4):1710-1720 (1999).
Bateman et al., Nucl. Acids Res., 30(1):276-280 (2002).
Bentley et al., Annu. Rev. Microbiol., 53:411-46 (1999).
Bisang et al., Nature, 401:502-505 (1999).
Bork, TIG, 12(10):425-427 (1996).
Brenner, TIG, 15(4):132-133 (1999).
Broun et al., Science, 282:1315-1317 (1998).
Chuck et al., Chem. and,Bio., Current Bio. (London, GB), 4:10 (1997) pp. 757-766.
Creelman et al., Annu. Rev. Plan Physiol. Plant Mol. Biol., 48:355-81 (1997).
Database Geneseq ′Online! Dec. 11, 2000, “S. aggregatumPKS cluster ORF6 homolog DNA.” XP002368912, retrieved from EBI accession No. GSN:AAA71567Database accession No. AAA71567—& Database Geneseq ′Online! Dec. 11, 2000, “S. aggregatumPKS cluster ORF6 homolog protein.” XP002368914 retrieved from EBI accession No. GSP:AAB10482 Database accession No. AAB10482 & WO 00/42195 A (Calgene, LLC) Jul. 20, 2000.
DeLong & Yayanos, Appl. Environ. Microbiol., 51(4):730-737 (1986).
Doerks, TIG, 14(6):248-250 (1998).
Facciotti et al., “Cloning and Characterization of Polyunsaturated Fatty Acids (PUFA) Genes from Marine Bacteria” in Proceedings of the international symposium on progress and prospect of marine biotechnology (China Ocean Pres 1999), pp. 404-405 Abstract.
GenBank Accession No. U09865. Alcaligenes eutrophus pyruvate dehydrogenase (pdhA), dihydrolipoamide acetyltransferase (pdhB), dihydrolipoamide dehydrogenase (pdhL), and ORF3 genes, complete cds (1994).
Harlow et al. Antibodies: A Laboratory Manual (1988) Cold Spring Harbor Laboratory Press, p. 76.
Heath et al., J. Biol. Chem., 271(44):27795-27801 (1996).
Hopwood & Sherman, Annu. Rev. Genet., 24:37-66 (1990).
Hutchinson, Annu. Rev. Microbiol., 49:201-238 (1995).
Jez et al., Chem. and Bio. (London), 7:12 (2000) pp. 919-930.
Jostensen & Landfald, FEMS Microbiology Letters, 151:95-101 (1997).
Katz & Donadio, Annu. Rev. Microbiol., 47:875-912 (1993).
Kealey et al., “Production of a polyketide natural product in non-polyketide-producing prokaryotic and eukaryotic hosts”, Proceedings of the National Academy of Sciences of the United States of America, vol. 95, No. 2, Jan. 20, 1998, pp. 505-509, XP002338563.
Keating et al., Curr. Opin. Chem. Biol., 3:598-606 (1999).
Kyle et al., HortScience, 25:1523-26 (1990).
Leadlay PF. Current Opinion in Chemical Biology (1997) 1: 162-168.
Magnuson, Microbil. Rev., 57(3):522-542 (1993) Abstract.
Metz et al., Science, 293:290-293 (2001).
Nakahara, Yukagaku, 44(10):821-7 (1995).
Nasu et al., J. Ferment. Bioeng., 122:467-473 (1997).
Nichols et al., Curr. Opin. Biotechnol., 10:240-246 (1999).
Nicholson et al., Chemistry and Biology (London), 8:2 (2001) pp. 157-178.
Nogi et al., Extremophiles, 2:1-7 (1998).
Oliynyk et al. Chemistry & Biology (1996) 3: 833-839.
Parker-Barnes et al., PNAS, 97(15):8284-8289 (2000).
Sanchez et al., Chemistry & Biolosy, 8:725-738 (2001).
Shanklin et al., Annu. Rev. Plant Physiol. Plant Mol. Biol., 49:611-41 (1998).
Smith et al., Nature Biotechnol., 15:1222-1223 (19

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

PUFA polyketide synthase systems and uses thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with PUFA polyketide synthase systems and uses thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and PUFA polyketide synthase systems and uses thereof will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4236818

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.