PTPN11 (SHP-2) mutations and cancer

Details PTPN11 (SHP-2) mutations and cancer PTPN11 (SHP-2) mutations and cancer

2003-11-05

2009-06-23

Johannsen, Diana B (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100, C435S019000, C435S091200, C435S091510, C435S196000, C435S287200, C536S023200, C536S023500, C536S025320

Reexamination Certificate

active

07550262

ABSTRACT:
Diagnostic and therapeutic applications for certain types of cancer and precancerous conditions, including those deriving from hematologic cells, are described. Of particular interest are those cancers and precancerous conditions associated with increased signaling in the RAS-MAP kinase pathway. The diagnostic and therapeutic applications described herein are based on certain mutations in the protein tyrosine phosphatase gene PTPN11 and its expression product, PTPN11, promoting a gain-of-function in PTPN11 activity. Also described are nucleotide sequences, amino acid sequences, probes, and primers related to PTPN11 and PTPN11 variants, and cells expressing such variants.

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