PTP-S31: A novel protein tyrosine phosphatase

Details PTP-S31: A novel protein tyrosine phosphatase PTP-S31: A novel protein tyrosine phosphatase

1993-03-23

1996-12-17

Horlick, Kenneth R.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 435 703, 435 711, 4352402, 4353201, 4352523, 536 232, 536 235, C12Q 168, C12P 1934, C07H 2104

Patent

active

055852335

ABSTRACT:
A novel protein tyrosine phosphatase designated PTP-S31 and its subfamily are identified, as are nucleic acid molecule coding therefor. Included in this family are PTP-S31 proteins or glycoproteins having one, two, or three identified amino acid changes in previously defined consensus sequences in the catalytic phosphatase domains of known protein tyrosine phosphatases. The PTP-S31 proteins or glycoproteins may be produced by recombinant means. Antibodies to PTP-S31 proteins or glycoproteins and nucleic acid constructs coding therefor, and methods for screening molecules which can bind to PTP-S31 proteins or glycoproteins and inhibit or stimulate their enzymatic activity, are provided.

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