PTP 1D: a novel protein tyrosine phosphatase

Details PTP 1D: a novel protein tyrosine phosphatase PTP 1D: a novel protein tyrosine phosphatase

1995-05-23

1999-11-09

Teng, Sally P.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

530350, 530300, 514 2, 435 691, C07K 14435, C12N 1555

Patent

active

059812516

ABSTRACT:
A novel protein tyrosine phosphatase is the protein designated PTP 1D. The PTP 1D protein may be produced by recombinant means, for example using a nucleic acid construct encoding the protein as provided herein. Also disclosed is an antibody specific for an epitope of PTP 1D, protein. Methods for identifying compounds which bind to a PTP 1D protein and inhibit or stimulate its enzymatic activity, pharmaceutical compositions comprising PTP 1D, and methods for treating a disease associated with PTP 1D protein using such compositions, are provided.

REFERENCES:
patent: 4675285 (1987-06-01), Clark et al.
Adalhi et al., Cancer Research, 52, 737-740, Feb. 1992.
Freeman et al., Identification of a human src homology 2-containing protetyrosine-phosphatase: A putative homolog of Drosophila corkscrew, Proc. Natl. Acad. Sci. USA 89: 11239-11243 (1992).
Matthews et al., Characterization of hematopoietic intracellular protein tyrosine phosphatases: Description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences, Mol. Cell. Biol., 12:2396-2405 (1992).
Plutzky et al., Isolation of src homology 2-containing tyrosine phosphatase, Proc. Natl. Acad. Sci. USA 89:1123-1127 (1992).
Yi et al., Protein tyrosine phosphatase containing SH2 domains: Characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13, Mol. Cell. Biol., 12:836-846 (1992).
Gu et al., Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1, Proc. Natl. Acad. Sci. USA 88:5867-5871 (1991).
Lombroso et al., Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum, Proc. Natl. Acad. Sci. USA 88:7242-7246 (1991).
Shen et al., A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases, Nature 352:736-739 (1991).
Yang and Tonks, Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin, Proc. Natl. Acad. Sci. USA 88:5949-5953 (1991).
Chernoff et al., Cloning of a cDNA for a major human protein-tyrosine-phosphatase, Proc. Natl. Acad. Sci. USA 87;2735-2739 (1990).
Guan et al., Cloning and expression of a protein-tyrosine-phosphatase, Proc. Natl. Acad. Sci. USA 87:1501-1505 (1990).
Charbonneau et al., Human placenta protein-tyrosine-phosphatase: Amino acid sequence and relationship to a family of receptor-like protein, Proc. Natl. Acad. Sci. USA 86:5252-5256 (1989).
Cool et al., cDNA isolated from a human T-cell library encodes a member of the protein-tyrosine-phosphatase family, Proc. Natl. Acad. Sci. USA 86:5257-5261 (1989).
Pallen et al., Purification of a phosphotyrosine phosphatase that dephosphorylates the epidermal growth factor receptor autophosphorylation sites, Ann. N.Y. Acad. Sci. 551:299-308 (1988).
Tonks et al., Purification of the major protein-tyrosine-phosphatases of human placenta, J. Biol. Chem. 263:6722-6730 (1988).
Gebbink et al., Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase, FEBS Lett., 290;123-130 (1991).
Jirik et al., Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase, FEBS Lett 273:239-242 (1990).
Kaplan et al., Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain, Proc. Natl. Acad. Sci. USA 87:7000-7004 (1990).
Krueger et al., Structural diversity and evolution of human receptor-like protein-tyrosine phosphatase, EMBO J. 9:3241-3252 (1990).
Matthews et al., Identification of a additional member of the protein-tyrosine-phosphatase family: Evidence for alternative splicing in the tyrosine phosphatase domain, Proc. Natl. Acad. Sci. USA 87:4444-4448 (1990).
Mustelin et al., Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase, Proc. Natl. Acad. Sci. USA 86:6302-6306 (1989).
Streuli et al., A new member of the immunoglobin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen, J. Exp. Med., 168:1523-1530 (1988).
Ralph et al., Structural variants of human T200 glycoprotein (leukocyte common antigen), EMBO J. 6:1251-1257 (1987).
Perkins et al., Corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinases torso, Cell 70:225-236 (1992).
Hariharan et al., Cloning and characterization of a receptor-class phosphotyrosine phosphatase gene expressed on central nervous system axons in Drosophila melanogaster, Proc. Natl. Acad. Sci. USA 88:11266-11270 (1991).
Streuli et al., A family receptor-linked protein tyrosine phosphatases in humans and Drosophila, Proc. Natl. Acad. Sci. USA 86:8698-8702 (1989).
Sprenger et al., The drosophila gene torso encodes a putative receptor tyrosine kinase, Nature 338:478-483 (1989).
Russell et al., Conservation analysis and structure prediction of the SH2 family of phosphotyrosine binding domains, FEBS Lett., 304(1):15-20 (1992).
Zheng et al., Cell transformation and activation of pp60 (c-src) by overexpression of a protein tyrosine phosphatase, Nature 359:336-339 (1992).
Stover et al., Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells, Proc. Natl. Acad. Sci., USA 88:7704-7707 (1991).
Margolis et al., EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling, Cell 57:1101-1107 (1989).
Morla et al., Reversible tyrosine phosphorylation of cdc2: Dephosphorylation accompnaies activation during entry into mitosis, Cell 58:193-203 (1989).
Charbonneau and Tonks, 1002 Protein phosphatases?, Ann. Rev. Cell. Biol.,8:463-493 (1992).
Pot and Dixon, A thousand and two protein tyrosine phosphatases, Biochem. Biophys. Acta., 1136:35-43 (1992).
Fischer et al., Protein tyrosine phosphatases: A diverse family of intracellular and transmembrane enzymes, Science 253:401-406 (1991).
Koch et al., SH2 and SH3 domains: Elements that control interactions of cytoplasmic signaling proteins, Science 252:668-674 (1991).
Hunter, Protein-tyrosine-phosphatases: The other side of the coin, Cell 58:1013-1016 (1989).
Hunter, A tail of two src's Mutatis mutandis, Cell 49:1-4 (1987).
Watson, J.D., in: Molecular Biology of The Gene, 3rd Edition, Benjamin/Cummings Publ. Co., Inc. Menlo Park, CA 94025, p. 313 (1987).
Hackh's Chemical Dictionary, (Grant, J., ed.) McGraw Hill Book Co., NY p. 236, (1969).
Vogel et al., Activation of a Phosphotyrosine Phosphatase by Tyrosine Phosphorylation, Science 259:1611-1614 (1993).
Baker et al., in: The Study of Biology, Fourth edition, Addison-Wesley Publ. Co., Reading, MA, p. 9, (1982).
Co et al., Evidence for a Novel Protein Tyrosine Phosphatase in Human Skeletal Muscle, Biophys. J. 61 (2 part 2), A337, abstract 1940, (1992).
Day, R.A., How to Write and Publish a Scientific Paper, Second Edition, ISI Press, Philadelphia, PA, pp. 15-19, (1983).
Zhang et al., Identification of Skeletal Muscle Protein-Tyrosine Phosphatases by Amplification of Conserved cDNA Sequences, Biochem. Biophys. Res. Commun. 178:1291-1297, (1991).
Adachi, M. et al., Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2, FEBS Letters, 314:3, (1992).

Affiliated with

Also associated with

Rating

PTP 1D: a novel protein tyrosine phosphatase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with PTP 1D: a novel protein tyrosine phosphatase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and PTP 1D: a novel protein tyrosine phosphatase will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1454438