PTH-like peptides

Details PTH-like peptides PTH-like peptides

2006-11-07

2006-11-07

Tsang, Cecilia J. (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

Reexamination Certificate

active

07132394

ABSTRACT:
The present invention relates to peptides that are parathyroid hormone (PTH) analogs, useful for the treatment of hypoparathyroidism and diseases characterized by bone mass reduction, such as osteoporosis, and for stimulating bone repair or favoring the engraftment of a bone implant; to the pharmaceutical compositions comprising these PTH-like peptides and use thereof.

REFERENCES:
patent: 5814603 (1998-09-01), Oldenburg et al.
Shimizu et al. “Parathyroid Hormone (PTH)-(1-14) and -(1-11) Analogs Conformationally Constrained by alpha-Aminoisobutyric Acid Mediate Full Agonist Responses via the Juxtamembrane Region of the PTH-1 Receptor” J. Biol. Chem. 2001, 276 (52), 49003-12.
Potts “Parathyroid hormone: past and present” J. Endocrin. 2005, 187, 311-25.

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