Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 25 or more amino acid residues in defined sequence
Reexamination Certificate
2006-06-06
2006-06-06
Li, Ruixiang (Department: 1646)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
25 or more amino acid residues in defined sequence
C514S012200
Reexamination Certificate
active
07057012
ABSTRACT:
Novel parathyroid hormone (PTH) peptides and analogs thereof of the PTH(1–34) fragment are disclosed that combine the N-terminal signaling domain (residues 1–9) and the C-terminal binding domain (residues 15–31) via a linker. Nucleic acid molecules and peptides for PTH(1–9)-(Gly)5-PTH(15–31) (PG5) and (1–9)-(Gly)7-PTH(15–31) and a novel PTH receptor are disclosed. Additionally, methods of screening for PTH agonists, pharmaceutical compositions and methods of treatment are disclosed.
REFERENCES:
patent: 4675189 (1987-06-01), Kent et al.
patent: 4698328 (1987-10-01), Neer et al.
patent: 4736866 (1988-04-01), Leder et al.
patent: 4761406 (1988-08-01), Flora et al.
patent: 5527772 (1996-06-01), Holick
patent: 5840690 (1998-11-01), Holick
patent: 5977070 (1999-11-01), Piazza et al.
Abou-Samra, A.-B., et al., “Non-Homologous Sequences of Parathyroid Hormone and the Parathyroid Hormone Related Peptide Bind to a Common Receptor on ROS 17/2.8 Cells,”Endocrinol. 125:2215-2217 (1989).
Azarani, A., et al., “Structurally Diverse N-terminal Peptides of Parathyroid Hormone (PTH) and PTH-related Peptide (PTHRP) Inhibit the Na+/H+Exchanger NHE3 Isoform by Binding to the PTH/PTHRP Receptor Type I and Activating Distinct Signaling Pathways,”J. Biol. Chem. 271:14931-14936 (1996).
Bergwitz, C., et al., “Full Activation of Chimeric Receptors by Hybrids between Parathyroid Hormone and Calcitonin,”J. Biol. Chem. 271:26469-26472 (1996).
Bergwitz, C., et al., “Residues in the Membrane-spanning and Extracellular Loop Regions of the Parathyroid Hormone (PTH)-2 Receptor Determine Signaling Selectivity for PTH and PTH-related Peptide,”J. Biol. Chem. 272:28861-28868 (Nov. 1997).
Bisello, A., et al., “Parathyroid Hormone-Receptor Interactions Identified Directly by Photocross-linking and Molecular Modeling Studies,”J. Biol. Chem. 273:22498-22505 (Aug. 1998).
Broadus, A.E. and Stewart, A.F., “Parathyroid Hormone-Related Protein Structure, Processing, and Physiological Actions,” inThe Parathyroids Basic and Clinical Concepts, Bilezikian et al., eds., Raven Press Ltd., New York, New York (1994).
Caulfield, M.P., et al., “The Bovine Renal Parathyroid Hormone (PTH) Receptor Has Equal Affinity for Two Different Amino Acid Sequences: The Receptor Binding Domains of PTH and PTH-Related Protein Are Located within the 14-34 Region,”Endocrinol. 127:83-87 (1990).
Cleland, J.L., et al., “The Development of Stable Protein Formulations: A Close Look at Protein Aggregation, Deamidation, and Oxidation,”Critical Rev. Ther. Drug. Carrier Sys. 10:307-377 (1993).
Cohen, F.E., et al., “Analogues of Parathyroid Hormone Modified at Positions 3 and 6. Effects on Receptor Binding and Activation of Adenylyl Cyclase in Kidney and Bone,”J. Biol. Chem. 266:1997-2004 (1991).
Colquhoun, D., Binding, gating, affinity, and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors,Br. J. Pharmacol. 125:924-947 (Nov. 1998).
Dautzenberg, F.M., et al., “Mapping of the ligand-selective domain of theXenopus laeviscorticotropin-releasing factor receptor 1: Implications for the ligand-binding site,”Proc. Natl. Acad. Sci. USA 95:4941-4946 (Apr. 1998).
Dempster, D.W., et al., “Anabolic Actions of Parathyroid Hormone on Bone,”Endocrine Rev. 14:690-709 (1993).
Dempster, D.W., et al., “Anabolic Actions of Parathyroid Hormone on Bone (Erratum),”Endocrine Rev. 15:261 (1994).
Gardella, T.J., et al., “Mutational Analysis of the Receptor-activating Region of Human Parathyroid Hormone,”J. Biol. Chem. 266:13141-13146 (1991).
Gardella, T.J., et al., “Analysis of Parathyroid Hormone's Principal Receptor-Binding Region by Site-Directed Mutagenesis and Analog Design,”Endocrinol. 132:2024-2030 (1993).
Gardella, T.J., et al., “Determinants of [Arg2]PTH-(1-34) Binding and Signaling in the Transmembrane Region of the Parathyroid Hormone Receptor,”Endocrinol. 135:1186-1194 (1994).
Gardella, T.J., et al., “Parathyroid Hormone (PTH)-PTH-related Peptide Hybrid Peptides Reveal Functional Interactions between the 1-14 and 15-34 Domains of the Ligand,”J. Biol. Chem. 270:6584-6588 (1995).
Gombert, F.O., et al., “Alanine and D-Amino Acid Scan of Human Parathyroid Hormone,” inPeptides: Chemistry. Structure and Biology, Pravin et al., eds., Mayflower Scientific Ltd., Switzerland, pp. 661-662 (1996).
Gardella, T.J., et al., “Converting Parathyroid Hormone-related Peptide (PTHrP) into a Potent PTH-2 Receptor Agonist,”J. Biol. Chem. 271:19888-19893 (1996).
Goltzman, D., et al., “Analysis of the Requirements for Parathyroid Hormone Action in Renal Membranes with the Use of Inhibiting Analogues,”J. Biol. Chem. 250:3199-3203 (1975).
Goud, N.A., et al., “Solid-Phase Synthesis and Biologic Activity of Human Parathyroid Hormone (1-84),”J. Bone Min. Res. 6:781-789 (1991).
Holtmann, M.H., et al., “Critical Contributions of Amino-terminal Extracellular Domains in Agonist Binding and Activation of Secretin and Vasoactive Intestinal Polypeptide Receptors,”J. Biol. Chem. 270:14394-14398 (1995).
Horiuchi, N. et al., “A Parathyroid Hormone Inhibitor in vivo: Design and Biological Evaluation of a Hormone Analog,”Science 220:1053-1055 (1993).
Ishihara, T., et al., “Molecular cloning and expression of a cDNA encoding the secretin receptor,”EMBO J. 10:1635-1641 (1991).
Jelinek, L.J., et al., “Expression Cloning and Signaling Properties of the Rat Glucagon Receptor,”Science 259:1614-1616 (1993).
Jüppner, H., et al., “The Parathyroid Hormone-like Peptide Associated with Humoral Hypercalcemia of Malignancy and Parathyroid Hormone Bind to the Same Receptor on the Plasma Membrane of ROS 17/2.8 Cells,”J. Biol. Chem. 263:8557-8560 (1988).
Jüppner, H., et al., “The Extracellular Amino-Terminal Region of the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Determines the Binding Affinity for Carboxyl-Terminal Fragments of PTH-(1-34),”Endocrinol. 134:879-884 (1994).
Karaplis, A.C., et al., “Lethal skeletal dysplasia from targeted disruption of the parathyroid hormone-related peptide gene,”Genes&Develop. 8:277-289 (1994).
Kolakowski, L.F., “GCRDb: A G-Protein-Coupled Receptor Database,”Receptors and Channels 2:1-7 (1994).
Kronenberg, H.M., et al., “Parathyroid Hormone: Biosynthesis, Secretion, Chemistry, and Action,” inPhysiol. Pharmacol. of Bone, Mundy, G.R. and Martin, T.J., eds., Springer-Verlag, Berlin pp. 508-567 (1993).
Lanske, B., et al., “PTH/PTHrP Receptor in Early Development and Indian Hedgehog-Regulated Bone Growth,”Science 273:663-666 (1996).
Lin, H.Y., et al., “Expression Cloning of an Adenylate Cyclase-Coupled Calcitonin Receptor,”Science 254:1022-1024 (1991).
Luck, M.D., et al., “The (1-14) Fragment of Parathyroid Hormone (PTH) Activates Intact and Amino-Terminally Truncated PTH-1 Receptors,”Mol. Endocrinol. 13:670-680 (May 1999).
Mannstadt, M., et al., “Evidence for a Ligand Interaction Site at the Amino-Terminus of the Parathyroid Hormone (PTH)/PTH-related Protein Receptor from Cross-linking and Mutational Studies,”J. Biol. Chem. 273:16890-16896 (Jul. 1998).
Nissenson, R.A., et al., “Synthetic Peptides Comprising the Amino-terminal Sequence of a Parathyroid Hormone-like Protein from Human Malignancies. Binding to Parathyroid Hormone Receptors and Activation of Adenylate Cyclase in Bone Cells and Kidney,”J. Biol. Chem. 263:12866-12871 (1988).
Nussbaum, S.R., et al., “Parathyroid Hormone-Renal Receptor Interactions,”J. Biol. Chem. 255:10183-10187 (1980).
Van Ostade, X., et al., “Human TNF mutants with selective activity on the p55 receptor,”Nature 361:266-269 (1993).
Pinc
Gardella Thomas J.
Jüppner Harald
Kronenberg Henry M.
Potts, Jr. John T.
Li Ruixiang
Sterne Kessler Goldstein & Fox P.L.L.C.
The General Hospital Corporation
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