PTH analogs for renal osteodystrophy and related uses

Details PTH analogs for renal osteodystrophy and related uses PTH analogs for renal osteodystrophy and related uses

2007-09-18

2007-09-18

Zara, J (Department: 1635)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S006120, C435S091100, C435S325000, C435S375000, C435S455000, C536S023100, C536S023200, C536S023500, C536S024500

Reexamination Certificate

active

10344744

ABSTRACT:
The invention relates to a mammalian cell lacking type-1 parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor (PTH1R) activity and containing carboxyl-terminal parathyroid hormone receptor (CPTHR) activity. The invention also relates to a method of screening for agonists or antagonists for CPTHR.

REFERENCES:
Divieti et al., J. Bone & Mineral Res., vol. 13, No. 12, pp. 1835-1845 (1998).
Lanske, B., et al., “Ablation of the PTHrP gene or the PTH/PTHrP receptor gene leads to distinct abnormalities in bone development,”J. Clin. Invest. 104:399-407, American Society for Clinical Investigation (Aug. 1999).
Divieti, P., et al., “Conditionally immortalized primary murine calvarial osteoblasts: A model of PTH action and PTH/PTHRP receptor ablation,”Eur. J. Clin. Invest. 25(suppl. 2) :A46, Abstract No. 263, Oxford Blackwell Scientific Publications (1995).
Wysolmerski, J.J., and Stewart, A.F., “The physiology of parathyroid hormone-related protein. An emerging role as a developmental factor,”Annu. Rev. Physiol. 60:431-460, Palo Alto Ca Annual Reviews (1998).

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