Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1995-05-26
1997-03-18
Jones, W. Gary
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 243, C07H 2104
Patent
active
056124686
ABSTRACT:
The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotides. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.
REFERENCES:
patent: 3792036 (1974-02-01), Pfleiderer
patent: 3798210 (1974-03-01), Pfleiderer
patent: 4371514 (1983-02-01), Nagatsu et al.
patent: 5270465 (1993-12-01), Ferrand et al.
patent: 5278043 (1994-01-01), Bannwarth et al.
patent: 5350749 (1994-09-01), Hackler et al.
Bannwrath, W. et al., "Energy Transfer from a Lumazine(=Pteridine-2,4(1H,3H)-dione) Chromophore to Bathophenanthroline-ruthenium (II) Complexes during Hybridization Processes of DNA", Helvetica Chimica Acta, vol. 74, 2000-2007 (1991).
Bannwrath, W. et al., "Energy Transfer within Oligonucleotides from a Lumazine (=Pterine-2, 4(1H, 3H)-dione) Chromophore to Bathophenanthroline-tuthenium(II) Complexes", Helvetica Chimica Acta, vol. 74, 1991-1999 (1991).
Bannwarth, W. et al., "Synthesis and Properties of Dinucleoside Monophosphates with Thymidine and 1-(2'-Deoxy-.beta.-D-ribofuranosyl) lumazines as Building Blocks**)", Liebigs Ann. Chem., 50-65 (1980).
Cao, X. et al., "Structure of Lumazine N.sup.1 -(2'-Deoxy-D-ribonucleosides) (=1-)2'-Deoxy-D-ribofuranosyl) pteridine-2,4(1H, 3H)-diones): A Revision of the Anomeric Configuration", Helvetica Chimica Acta, vol. 75, 1267-1273 (1992).
Charubala, R. et al., "Synthesis and Properties of Trinucleoside Diphosphates with Thymidine, 2'-Deoxyadenosine, and 1-(2'-Deoxy-.alpha.and 1-(2'-Deoxy-.beta.-D-ribofuranosyl) lumazines as Building Blocks**)", Liebigs Ann. Chem., 65-79 (1980).
Davis, M. et al., "Charge Transfer Complexes between Pteridine Substrates and the Active Center Molybdenum of Xanthine Oxidase", J. Biol. Chem., 257, vol. 24, 14730-14737 (1982).
Davis, M. et al., "The Reaction of Xanthine Oxidase with Lumazine", J. Biol. Chem., 259 vol. 6, 3526-3533 (1984).
Harris, R. et al., "Synthesis and Properties of 4-Amino-8-.beta.-D-ribofuranosyl-7 (8H)-pteridinone and its 2-und 6-Phenyl Derivatives", Liebigs Ann. Chem., 1457-1468 (1981).
Himmelsbach, F. et al., "The p-Nitrophenylethyl (NPE) Group: A Versatile New Blocking Group for Phosphate and Aglycone Protection in Nucleosides and Nucleotides", Tetrahydron vol. 40, No.1, 59-72 (1984).
Itoh, T. et al., "Ribosidation of 2-Dimethylamino-4, 7-dioxo-tetrehydropteridine and it 4-Benzyloxy Derivative", Chem. Ber., vol. 109, 3228-3242, (1976).
Kiriasis, L. et al., "Synthesis and Properties of New Pteridine Nucleosides", [in?] Chemistry and Biology of Pteridines, Kisliuk/Brown, eds., 49-53 (1979).
Ott, M. et al., "Synthesis of 4-Amino-7-oxo-7, 8-dihydropteridine-N-8-.beta.D-ribofuranoside A Structural Analogue of Adosine", Chem. Ber. vol. 107, 339-361, (1974).
Ritzmann, G. et al., "Improved Syntheses of Lumazine Nucleosides", Liebigs Ann. Chem., 1217-1234 (1977).
Ritzmann, G. et al., "Synthesis and Properties of Lumazine Nucleotides -Structural Analogs of Urdine and Thymidine", vol. 106, 1407-1417 (1973).
Schmid, H. et al., "Synthesis of Isoxanthopterin-N-8-.beta.-D-ribofuranoside -A Structural Analog of the Nucleoside Guanosine", Chem. Ber. vol. 106, 1952-1975 (1973).
Taira, et al. "Evaluation of the Importance of Hydrophobic Interactions in Drug Binding to Dihydrofolate Reductase", J. Med. Chem. vol. 31, 1129-137 (1988).
Balis Frank
Davis Michael D.
Hawkins Mary E.
Pfleiderer Wolfgang
Atzel Amy
Jones W. Gary
The United States of America as represented by the Department of
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