Pteridine derivatives and method of treating leukemia employing

Details Pteridine derivatives and method of treating leukemia employing Pteridine derivatives and method of treating leukemia employing

1986-01-27

1989-04-11

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514258, 544258, 544260, 544261, A61K 31505, C07D47504, C07D47508

Patent

active

048207063

ABSTRACT:
2,4-Diaminopteridine derivatives and the pharmaceutically acceptable salts thereof having potent anticancer activity are disclosed. The derivatives possess the structural formula: ##STR1## wherein Y is NH.sub.2, OH or SH, R is ##STR2## and X is ##STR3## in which R' is H or CH.sub.3 or ##STR4## in which R and R' are as previously defined, provided when Y is NH.sub.2, R' must be CH.sub.3 and when Y is OH, R' must be OH.

REFERENCES:
patent: 2563707 (1951-08-01), Cosulich
patent: 2766240 (1956-10-01), Geraci
Cutting; W. C., Cutting's Handbook of Pharmacology, 4th ed. (1969: Appleton-Century-Crofts; New York), pp. 140-141.
Burger, A., Medicinal Chemistry, 2nd Ed., Interscience Publishers, Inc., New York, N.Y. (1960) pp. 1080-1085.
Henkin, J. et al., J. Med. Chem., 1983, 26, pp. 1193-1196.
Piper, J. R. et al., J. Med. Chem., 1985, 28, pp. 1016-1025.
Bunton, C. A. et al., J. Am. Chem. Soc., 1974, 96, pp. 3267-3275.

Affiliated with

Also associated with

Rating

Pteridine derivatives and method of treating leukemia employing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pteridine derivatives and method of treating leukemia employing , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pteridine derivatives and method of treating leukemia employing will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-667412