Psychotropic polycyclic imides

Details Psychotropic polycyclic imides Psychotropic polycyclic imides

1988-12-19

1990-03-20

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540521, 546 68, 548424, C07D47100, C07D20956, C07D48704, C07D22316

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active

049103024

ABSTRACT:
Compounds of the formula: ##STR1## in which Z is ##STR2## wherein X is alkylene, ethanylene or alkylidene; Q is alkylene, alkylidene, ##STR3## or Q, taken together with the carbon atoms to which it is attached forms a benzene ring or a substituted benzene ring, in which said substituents are --OH, --OCH.sub.3, alkyl, halo, --CF.sub.3, --NH.sub.2, monoalkylamino, dialkylamino or alkanoylamino; R.sup.1 is hydrogen or alkyl; R.sup.2 and R.sup.3 are, independently, hydrogen or alkyl or taken together with the carbon atoms to which they are attached, they form a cycloalkane or cycloalkene ring; m is one of the integers 2-5; R.sup.4 is hydrogen, hydroxy, cyano, alkyl, alkoxy, halo, amino, alkylamino, phenylamino, tolylamino, xylylamino, mesitylamino, methoxyphenylamino, or halophenylamino; and the dotted lines represent optional unsaturation; or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 3944549 (1976-03-01), Laflon
patent: 3993662 (1976-11-01), Brechbuhler et al.
patent: 4061763 (1977-12-01), Shepard et al.
Derwent Abstract-87-118063/17 of GB 2,181,731.
Abstract of U.S. Pat. No. 3,993,662-Nov. 23, 1976.
Derwent Abstract-76-30495X/17 of German 2,544,382.
Fozard et al., Br. J. Pharmacol 90, 273 P (1987).

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