Psychotropic deuterated derivatives of phenylhydantoin and pharm

Details Psychotropic deuterated derivatives of phenylhydantoin and pharm Psychotropic deuterated derivatives of phenylhydantoin and pharm

1980-02-20

1981-12-08

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548314, A61K 31415

Patent

active

043047823

ABSTRACT:
Psychotropic composition comprising as an active constituent, a pharmaceutical composition, more particularly a psychotropic composition, characterized in that it comprises as an active constituent, a deuterated phenylhydantoin corresponding to the general formula ##STR1## wherein radicals R.sub.1 are identical or different and represent hydrogen or methyl, R.sub.2 is ethyl or a substituted or unsubstituted phenyl group, which is deuterated or not, R.sub.3 is hydrogen, halogen or a linear or ramified alkyl radical comprising 1 to 4 carbon atoms, a linear or ramified alkoxy radical comprising 1 to 4 carbon atoms, a trifluoromethyl, hydroxy, nitro or amino radical, X is an oxo, thio or methylene group and x is an integer of 1-5, one of its enantioners or one of its salts with a physiologically acceptable base, in combination with a pharmaceutically acceptable vehicle.

REFERENCES:
Chemical Abstracts, 88:105220s (1978) [Casey et al., J. Labelled Compd. Radiopharm. 1977, 13(4), 623-625].
Coombe, R. et al., Aust. J. Chem., 1978, 31, 451-453.
Chemical Abstracts, 84:59303p (1976) [Kepler, J., J. Labelled Compd. 1975, 11(4), 601-603].
Casey, D. et al., J. Labelled Compd. Radiopharm. 1977, 13(4), 623-625.
Baty, J. et al., Biomed. Mass Spec., 4(1), 36-41 (1977).

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