Psychoactive propargylamine derivatives used in the treatment of

Details Psychoactive propargylamine derivatives used in the treatment of Psychoactive propargylamine derivatives used in the treatment of

1993-11-26

1995-07-25

Henley, III, Raymond

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514315, 514317, 514351, 514367, 514461, 514646, 514625, A61K 3113, A61K 3147, A61K 31445, A61K 31425

Patent

active

054362733

ABSTRACT:
Propargylamine derivatives having the general formula: ##STR1## wherein R is a hydrogen atom, an unsubstituted phenyl group or a phenyl group substituted with halogen, trifluoromethyl, loweralkoxy, nitro, cyano, amido or N,N-diloweralkylamido, R.sub.1, R.sub.2 or R.sub.3 are the same or different and each represent a hydrogen atom or a loweralkyl group, R.sub.4 is a hydrogen atom or a loweralkyl, benzyl, phenethyl or furyl group, or R.sub.3 and R.sub.4 together with the nitrogen atom to which they are attached form a piperidinyl group, and their pharmaceutically acceptable acid addition salts, have been found to be useful in the treatment of anxiety, psychotic states and aggressive behavior in affected animals.

REFERENCES:
M. M. Kwatra et al., Journal of Medicinal Chemistry, vol. 21, No. 3, 1978, pp. 253-257.
D. Z. Simon et al., Journal of Medicinal Chemistry, vol. 13, No. 6, 1970, pp. 1249-1250.
S. Lipper et al., Psychopharmacology, vol. 62, No. 2, 1979, pp. 123-128.
J. O. Cole, Medical Clinics of North America, vol. 72, 1988, pp. 815-830.
Medline Abstracts, Accession No. 90081512 & Med. J. Aust. 1989, 151(11-12), pp. 697-701 (abstract enclosed).
Medlin Abstracts, Accession No. 88086954 & J. Clin. Psychiatry 1987, vol. 48, Suppl., pp. 7-11 (abstract enclosed).
Medline Abstracts, Accession No. 84239636 & J. Clin. Psychiatry, 1984, vol. 45, No. 7, pp. 70-77, (abstract enclosed).
Y. C. Martin et al, Journal of Medicinal Chemistry (1975), vol. 18 (#9) pp. 883-888.
Journal of Medicinal Chemistry, 1978, vol. 21, No. 3, pp. 253-257, Kwatra, Madan, Simon, D. Salvador, R. and Cooper, L.

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