Psuedomonas exotoxins of low animal toxicity and high cytocidal

Details Psuedomonas exotoxins of low animal toxicity and high cytocidal Psuedomonas exotoxins of low animal toxicity and high cytocidal

1995-06-06

1998-01-06

Feisee, Lila

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugated to proteinaceous toxin or fragment thereof

4241921, 4242361, 4242601, 5303917, 935 10, A61K 39395, A61K 3900, A61K 3902, A61K 39108

Patent

active

057051569

ABSTRACT:
Improved Pseudomonas exotoxins of low animal toxicity and high cytocidal activity are described. Substitution of positively charged amino acid residues with an amino acid residue without a positive charge provides markedly changed exotoxins. Conjugation of the new exotoxins with suitable targeting agents provides cytocidal specificity for killing desired cellular entities.

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