Psoralens aminomethylation

Details Psoralens aminomethylation Psoralens aminomethylation

1988-07-14

1990-08-21

Fan, Jane T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D49304

Patent

active

049507702

ABSTRACT:
A direct, acid-catalyzed substitution reaction incorporates an N-phthalimidomethyl group on the 4' or 5' carbon of a psoralen in yields of 60-80% via the condensation of an N-hydroxymethylamide or phthalimide (e.g. N-hydroxymethylphthalimide) and an appropriately substituted psoralen. The phthalimide moiety is cleaved from the psoralen ring by treatment with hydrazine to give 60 to 70% yields of the aminomethylpsoralens.

REFERENCES:
patent: 4124598 (1978-11-01), Hearst et al.
patent: 4294822 (1981-10-01), Kaufman
patent: 4465842 (1984-08-01), Desbois et al.

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