Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-10-20
1978-11-07
Trousof, Natalie
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260326D, 536 22, 424180, C07D49304
Patent
active
041245989
ABSTRACT:
New psoralen compounds have been synthesized. The compounds all include the addition of substituent groups at the 4' position on the basic trioxsalen structure. Specifically, the compounds have the structure: ##STR1## wherein X may be any desired substituent such as halogenated alkyls, alcohols, ethers, aminoalkyls, etc. The new substituted psoralens exhibit high solubility in aqueous solution and low dissociation constants from deoxyribonucleic acid (DNA), as well as a reactivity with ribonucleic acids (RNA). Such psoralen compounds find use in the study of secondary structures of nucleic acids; as inhibitors of RNA replication; in the inactivation of viruses; and in the photo chemotherapy of psoriasis.
REFERENCES:
patent: 3201421 (1965-08-01), Kaufman
Musajo et al., Chemical Abst., vol. 79, 1973, 27942b.
Ben-Hur et al., Chem. Abst., vol. 80, 1974 116713r.
Hearst John E.
Isaacs Stephen
Rapoport Henry
Shen Che-Kun J.
Fan Jane T.
Gould George M.
Hoffmann-La Roche Inc.
Trousof Natalie
Welt Samuel L.
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