Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1978-08-31
1980-04-01
Brown, Johnnie R.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 27, 536 29, 424180, C07H 1700, C07H 2102, C07H 2104
Patent
active
041962818
ABSTRACT:
New psoralen compounds have been synthesized. The compounds all include the addition of substituent groups at the 4' position on the basic trioxsalen structure. Specifically, the compounds have the structure: ##STR1## wherein X may be any desired substituent such as halogenated alkyls, alcohols, ethers, aminoalkyls, etc. The new substituted psoralens exhibit high solubility in aqueous solution and low dissociation constants from deoxyribonucleic acid (DNA), as well as a reactivity with ribonucleic acids (RNA). The psoralen-DNA and psoralen-RNA adducts are useful as a substrate for studying the secondary structures of nucleic acids.
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Hearst John E.
Isaacs Stephen
Rapoport Henry
Shen Che-Kun J.
Brown Johnnie R.
Gould George M.
Hazel Blondel L.
Regents of the University of California
Saxe Jon S.
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