Pseudorabies virus vaccine

Details Pseudorabies virus vaccine Pseudorabies virus vaccine

1996-07-22

1998-04-14

Mosher, Mary E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Virus or component thereof

4241991, 4242291, 4351721, 4351723, 4352351, 4353201, 435325, 435236, 4352523, 536 2372, 935 65, A61K 39245, C12N 510, C12N 704, C12N 1538

Patent

active

057388547

ABSTRACT:
The present invention is concerned with the preparation of a pseudorabies virus (PRV) mutant, formed by a mutation in open reading frame 1 of the BamHI fragment 4. The invention also relates to a PRV mutant containing a heterologous gone encoding an antigen of a porcine pathogan, which is incorporated into ORF1 of the BamHI fragment 4 nucleic acid. Such a PRV mutant can be used as a vector vaccine to induce an immune response after infection in an appropriate host animal. In addition, the PRV mutant is suitable for distinguishing between animals infected by the vaccine virus and animals infected by naturally-occurring viruses.

REFERENCES:
patent: 4650677 (1987-03-01), Roerink
Lomniczi, B.A. et al. 1984. Journal of Virology, vol. 52, pp. 198-205.
Lomniczi, B.A. et al. 1987. Journal of Virology, vol. 61, pp. 796-801.
Ladin, B.F. et al. 1982. Virology, vol. 116, pp. 544-561.
De Wind, N. et al. Journal of Virology, vol. 66, pp. 7096-7103 Dec. 1992.
Klupp, B.G. et al. Dec. 1992. Virology, vol. 191, pp. 900-908.
Mettenleiter, T.C. et al. Journal of Virology, vol. 62, pp. 2712-2717 1988.

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